Peer Reviewed Publications
Dohnalova, L, Lundgren, P, Carty JRE, Goldstein, N, Litchevskiy, L, Descamps, HC, Chellappa, K, Kessler, S, Cox, TO, Dmitrieva-Posocco, O, Wong, AC, Cornes, B, Churchill, GA, Baur, JA, Levy, M, Betley, JN,Thaiss, CA. 2021. A meta-organismal pathway regulates the motivation for exercise. In Press, Nature.
Low AYT, Goldstein N, Gaunt J, Huang KP, Zainolabidin N, Yip A, Carty JRE, Choi JY, Ho H, Lenherr C, Baltar N, Azim E, Sessions O, Ch’ng TH, Bruce AS, Martin LE, Halko RO, Holsen LM, Alhadeff AL, Chen AI, Betley JN. 2021. Reverse-translational identification of a cerebellar satiation network. Nature. doi:10.1038/s41586-021-04143-5
Goldstein N, Carty, JRE, Betley JN. 2021. Specificity of varenicline in blocking mesolimbic circuit activation to natural and drug rewards. Neuroscience. doi: 10.1016/j.neuroscience.2021.
Zhang, Y. F., Vargas Cifuentes, L., Wright, K. N., Bhattarai, J. P., Mohrhardt, J., Fleck, D., Janke, E., Jiang, C., Cranfill, S. L., Goldstein, N., Schreck, M., Moberly, A. H., Yu, Y., Arenkiel, B. R., Betley, J. N., Luo, W., Stegmaier, J., Wesson, D. W., Spehr, M., Fuccillo, M. V. & Ma, M. Ventral striatal islands of Calleja neurons control grooming in mice. Nature neuroscience 24, 1699-1710, doi:10.1038/s41593-021-00952-z (2021).
Dong Y, Carty J, Goldstein N, He Z, Hwang E, Chau D, Wallace B, Kabahizi A, Lieu L, Gao Y, Hu L, Betley JN, Williams KW. 2021. Time and metabolic state dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in-vivo. Molecular Metabolism, 54, 101352.
Goldstein N, McKnight AD, Carty JRE, Arnold M, Betley JN, and Alhadeff AL. 2021. Hypothalamic detection of macronutrients via multiple gut-brain pathways. Cell Metabolism, 33(3) 676-687. PMCID: PMC7933100.
Alhadeff AL, Park O, Hernandez E, and Betley JN. 2020. Inhibition of Itch by Hunger and AgRP Neuron Activity. Neuroscience 450, 126-134.
Lieu L, Chau D, Afrin S, Dong Y, Alhadeff AL, Betley JN, and Williams KW. 2020. Effects of metabolic state on the regulation of melanocortin circuits. Physiology & behavior 224, 113039.
Suh SE, Jun JV, Hernandez E, Tran MN, Betley JN, Chenoweth DM. 2020. A rapid synthesis of nuclear-staining small fluorescent molecules for brain imaging. Cell Reports Physical Science, 1(10)100227.
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW. 2019. Hypothalamic mTORC2 is essential for metabolic health and longevity. Aging Cell, 18(5)E13014.
Alhadeff AL, Goldstein N, Klima ML, Park O, Vargas A, Betley JN. 2019. Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits. Neuron, 103:891-908.
He Z, Gao Y, Alhadeff AL, Castorena CM, Huang Y, Lieu L, Afrin S, Sun J, Betley JN, Guo H, Williams KW. 2018. Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise. Molecular Metabolism 18:107-119.
Alhadeff AL, Su Z, Hernandez E, Klima MK, Phillips SZ, Holland RA, Guo C, Hantman AW, De Jonghe BC, Betley JN. 2018. Discovery of a neural circuit for the suppression of pain by a competing need state. Cell, 173(1): 140-52.
Su Z, Alhadeff AL, Betley JN. 2017. Nutritive, post-ingestive signals are the primary regulators of AgRP neuron activity. Cell Reports 21(10):2724-36.
Sternson SM, Atasoy D, Betley JN, Henry FE, Xu S. 2015. An emerging technological framework for the neurobiology of appetite. Cell Metabolism 23(2):234-53.
Betley JN, Xu S, Cao ZF, Gong R, Magnus CJ, Yu Y, Sternson SM. 2015. Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature 521(7551):180-85.