The Center for Mathematical Biology is the focal point for interdisciplinary research in mathematics and biology at the University of Pennsylvania. The research interests of the core members of Center range from ecology and evolutionary genetics to physiology and biophysics, on the one hand, and game theory, probability, partial differential equations and numerical analysis on the other.

The Simons Postdoctoral Fellows are a central part of the Center. The fellows are intellectually independent, but work together with core members. Short and long-term visitors are invited as speakers in a regular seminar series, as well as to participate in focused workshops on research topics of current interest.

Major funding for the Center comes from the Math + X grant awarded to the University of Pennsylvania through the Simons Foundation.