A recent paper from the group on the functional pairing between glycoconjugates and galectins has been highlighted in a Commentary in the Proceedings of the National Academy of Sciences (PNAS), written by Kamil Godula of UC San Diego. The original paper, also published in PNAS and led by Qi Xiao, unravels intricate aspects of the mechanism underlying the interactions between the cell glycan and proteins in its environment.
Feature image adapted from Kamil Godula’s Commentary.
Recent work published by the group in Polymer Chemistry utilizes one of the key features of single-electron transfer-living radical polymerization (SET-LRP): the high chain end functionality of the resulting polymers. In this work, led in our group by Adrian Moreno with contributions from Ryan L. Jezorek and Tong Liu, functional end groups of poly(methyl acrylate) (PMA) are exploited for esterification to generate PMA macromonomers and telechelics.
This work was conducted as part of a collaboration with the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.
The group has published a new paper in Proceedings of the National Academy of Sciences. The work presents a platform for interrogating the binding interactions between lectins and carbohydrates via agglutination assays. This approach is applied to understand the complex interplay between lectin structure, glycodendrimersome surface charge, glycan density, and cross-linking.
The work was led in our group by Qi Xiao with contributions from Irene Buzzacchera and Samuel E. Sherman, as part of a multidisciplinary collaborative effort with the groups of Hans-Joachim Gabius (Ludwig-Maximilians-University, Munich, Germany), Daniel A. Hammer (Penn), Michael L. Klein (Temple University, Philadelphia) and Martin Möller (RWTH Aachen University, Aachen, Germany).
The group has published a new paper in Polymer Chemistry. The work examines the replacement of Me6-TREN, a common ligand for SET-LRP, by TREN, which is 80 times cheaper. It is shown that high chain end functionality and controlled polymer growth can be achieved in a diverse range of water-organic solvent mixtures, further reducing the cost of SET-LRP for large-scale application.
The work was led in our group by Adrian Moreno and Silvia Grama, as part of a collaboration with the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.
A paper recently published by the group in Angewandte Chemie International Edition has been designated as a Hot Paper. The paper reports the use of glycodendrimersomes as a platform for the interrogation of sugar binding to a variety of natural and engineered human lectins, to examine the impact of spatial factors on aggregation activity. It was discovered that two aspects of lectin functionality respond non-uniformly to structural changes in the lectins.
The work was led in our group by Qi Xiao in collaboration with researchers from Ruprecht-Karls-University Heidelberg (Germany), Ludwig-Maximilians-University Munich (Germany), CSIC Ramiro de Maeztu (Spain), and Temple University (Philadelphia, PA).