Latest Paper in PNAS Unravels the Complexity of Lectin-Carbohydrate Interactions

The group has published a new paper in Proceedings of the National Academy of Sciences. The work presents a platform for interrogating the binding interactions between lectins and carbohydrates via agglutination assays. This approach is applied to understand the complex interplay between lectin structure, glycodendrimersome surface charge, glycan density, and cross-linking.

The work was led in our group by Qi Xiao with contributions from Irene Buzzacchera and Samuel E. Sherman, as part of a multidisciplinary collaborative effort with the groups of Hans-Joachim Gabius (Ludwig-Maximilians-University, Munich, Germany), Daniel A. Hammer (Penn), Michael L. Klein (Temple University, Philadelphia) and Martin Möller (RWTH Aachen University, Aachen, Germany).

New Work Uses Cheaper TREN as Ligand for SET-LRP

The group has published a new paper in Polymer Chemistry. The work examines the replacement of Me6-TREN, a common ligand for SET-LRP, by TREN, which is 80 times cheaper. It is shown that high chain end functionality and controlled polymer growth can be achieved in a diverse range of water-organic solvent mixtures, further reducing the cost of SET-LRP for large-scale application.

The work was led in our group by Adrian Moreno and Silvia Grama, as part of a collaboration with the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.

New Paper in Angewandte Chemie Designated as a Hot Paper

A paper recently published by the group in Angewandte Chemie International Edition has been designated as a Hot Paper. The paper reports the use of glycodendrimersomes as a platform for the interrogation of sugar binding to a variety of natural and engineered human lectins, to examine the impact of spatial factors on aggregation activity. It was discovered that two aspects of lectin functionality respond non-uniformly to structural changes in the lectins.

The work was led in our group by Qi Xiao in collaboration with researchers from Ruprecht-Karls-University Heidelberg (Germany), Ludwig-Maximilians-University Munich (Germany), CSIC Ramiro de Maeztu (Spain), and Temple University (Philadelphia, PA).