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Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

  • August 2016 – We welcome post-doc Melissa Birol in her move from New Haven to Philadelphia.
  • August 2016 – We say goodbye to Quinn and Lina – it was great having you in the lab on Team Tau for the summer!
  • July 2016 – Liz gave a talk and Melissa presented a poster at the FASEB Meeting on Protein Folding in the Cell. It was a fantastic meeting (even with lots of gels and chaperones).
  • July 2016 – We received an R01 from the NIH to study tau in relation to Alzheimer’s disease, a collaboration with the Odde and Sachs labs at the University of Minnesota.
  • June 2016 – We say farewell to Dong as he begins a position at China Agricultural University in Beijing. Good luck Dong!
  • June 2016 – Ana, Xiaohan, and Liz attended the GRS/GRC on Intrinsically disordered proteins in Les Diablerets, Switzerland. Liz was elected co-Chair of the 2020 meeting!
  • June 2016 – We welcome high school student Quinn Marks and high school teacher Lina Bader to the lab.
  • June 2016 – Kristen earned a slot on the Chemical Biology Training grant. Congratulations Kristen!
  • June 2016 – We welcome BMB graduate students Sanju Wickramasinghe and Kristen McKibben to the lab.

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