Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

  • May 2017 – Congratulations to Xiaohan Li on successfully defending his thesis!
  • April 2017 – Sanju passed prelims; Buyan passed candidacy – congratulations to them both!
  • Feb 2017 – Members of the Rhoades lab presented posters (Siobhan Toal, Xiaohan Li, and Melissa Birol) and a talk (Ana Melo) at the Biophysical Society Annual Meeting in New Orleans.
  • January 2017 – Liz became the Associate Editor of the Proteins section of the Biophysical Journal.
  • January 2017 – We welcome BMB rotation students Karen Acosta and Olivia Dickens to the lab.
  • October 2016 – We welcome Chemistry rotation student Sunbin Deng to the lab.
  • September 2016 – We welcome BMB rotation student Charlotte Fare to the lab.
  • August 2016 – We welcome post-doc Melissa Birol in her move from New Haven to Philadelphia.
  • August 2016 – We say goodbye to Quinn and Lina – it was great having you in the lab on Team Tau for the summer!
  • July 2016 – Liz gave a talk and Melissa presented a poster at the FASEB Meeting on Protein Folding in the Cell. It was a fantastic meeting (even with lots of gels and chaperones).
  • July 2016 – We received an R01 from the NIH to study tau in relation to Alzheimer’s disease, a collaboration with the Odde and Sachs labs at the University of Minnesota.

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