Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

  • June 2018 – Jonathan Musila from the Ellis Lab at Auburn University and the Rokita Lab at Johns Hopkins University joins us as a postdoc – welcome Jonathan!
  • June 2018 – We received a grant from the Michael J. Fox foundation to study the interaction of alpha-synculein with extracellular glycans.
  • May 2018 – We say good-bye to undergraduates Richard (Roger) and Hope – best of luck in your next steps!
  • May 2018 – Karen passed her prelims – way to go, Karen!
  • April 2018 – Liz gave a talk at the ASBMB Annual Meeting in San Diego
  • April 2018 – Melissa’s paper on IAPP came out in Nature Communications. Congratulations Melissa!
  • April 2018 – Joyce and Melissa’s paper on IDPs in macromolecular complexes appears in Current Opinion in Structural Biology.
  • February 2018 – Karen, Buyan and Kristen all presented posters at the Biophysical Society Annual meeting in San Francisco. Sanju gave a platform talk.
  • January 2018 – Buyan’s co-author paper with the Petersson Lab (and with lab alumnus Abhi Nath) is in print in the Biophysical Journal. Congratulations Buyan!
  • January 2018 – We welcome BMB rotation students Isabel Yannatos and Faviolla Báez Cruz to the lab.

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