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Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

          • September 2019 – We say goodbye to postdoc Jonathan – good luck in North Carolina!
          • August 2019 – Sanju’s paper on tau aggregation by polyphosphate with the Jakob lab came out in Biophysical Journal.
          • July 2019 – Jenny Ramirez joins the lab as a joint student with the Petersson lab. Welcome, Jenny!
          • July 2019 – Buyan’s collaborative paper on the structure and mechanism of NatA/Naa50 with the Marmorstein lab came out in Structure.
          • June 2019 – Liz gave talks at the GRC on Proteins and the FASEB meeting on Protein Aggregation.
          • June 2019 – Buyan presented a poster at the American Peptide Society meeting and won a Peptide Science Poster Award.
          • May 2019 – Congratulations to Melissa for her paper on alpha-synuclein and N-linked glycans being accepted at PLoS Biology!
          • May 2019 – Liz gave a keynote address at the Chesapeake Bay Single Molecule Meeting at the Janelia Research Campus.
          • May 2019 – We say good-bye to Adriana. We are delighted she will be returning to UPenn as a PhD student this summer!
          • May 2019 – Buyan presented a poster at the NYAS Chemical Biology Meeting and won a poster prize. Congratulations, Buyan!
          • May 2019 – Congratulations to Isabel on passing her candidacy exam!

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