Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

    • May 2019 – Congratulations to Melissa for her paper on alpha-synuclein and N-linked glycans being accepted at PLoS Biology!
    • May 2019 – Liz gave a keynote address at the Chesapeake Bay Single Molecule Meeting at the Janelia Research Campus.
    • May 2019 – We say good-bye to Adriana. We are delighted she will be returning to UPenn as a PhD student this summer!
    • May 2019 – Buyan presented a poster at the NYAS Chemical Biology Meeting and won a poster prize. Congratulations, Buyan!
    • May 2019 – Congratulations to Isabel on passing her candidacy exam!
    • March 2019 – Sanju, Karen, Buyan, Joyce and Jonathan presented posters at the Biophysical Society Annual Meeting in Baltimore. Kristen gave a platform talk and Liz gave a talk in the Awards Symposium.
    • February 2019 – We welcome Mushu, our new TIRF microscope, to the laser lab! We hope you and Wall-E get along and we look forward to working with you, Mushu!
    • January 2019 – Buyan’s collaborative paper on alpha-synuclein with the Ischiropolous lab was published in Scientific Reports.
    • December 2018 – Liz’s volume of Methods in Enzymology on Intrinsically Disordered Proteins came out.
    • July 2018 – We welcome new lab member, Isabel, to the group and congratulate her for being selected as a trainee on the Structural Biology and Molecular Biophysics Training grant. Way to go, Isabel!
    • July 2018 – We welcome Adriana Naomi Santiago-Ruiz, a post-bacc student from the University of Puerto Rico at Cayey, to the lab.
    • June 2018 – Jonathan Musila from the Ellis Lab at Auburn University and the Rokita Lab at Johns Hopkins University joins us as a postdoc – welcome Jonathan!
    • June 2018 – We received a grant from the Michael J. Fox foundation to study the interaction of alpha-synculein with extracellular glycans.

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