Citation:
2016. Tug of war: adding and removing histone lysine methylation in Arabidopsis, Sep 7. Curr Opin Plant Biol. 34:41-53.
Abstract:
Histone lysine methylation plays a fundamental role in the epigenetic regulation of gene expression in multicellular eukaryotes, including plants. It shapes plant developmental and growth programs as well as responses to the environment. The methylation status of certain amino-acids, in particular of the histone 3 (H3) lysine tails, is dynamically controlled by opposite acting histone methyltransferase ‘writers’ and histone demethylase ‘erasers’. The methylation status is interpreted by a third set of proteins, the histone modification ‘readers’, which specifically bind to a methylated amino-acid on the H3 tail. Histone methylation writers, readers, and erasers themselves are regulated by intrinsic or extrinsic stimuli; this forms a feedback loop that contributes to development and environmental adaptation in Arabidopsis and other plants. Recent studies have expanded our knowledge regarding the biological roles and dynamic regulation of histone methylation. In this review, we will discuss recent advances in understanding the regulation and roles of histone methylation in plants and animals.
Notes:
Xiao, JunLee, Un-SaWagner, DorisENGREVIEW2016/09/11 06:00Curr Opin Plant Biol. 2016 Sep 7;34:41-53. doi: 10.1016/j.pbi.2016.08.002.