Representative publications, for full list see here.
Bonini, NM. (2022). A perspective on Drosophila genetics and its insight into human neurodegenerative disease. Front Mol Biosci. 9, 1060796. doi: 10.3389/fmolb.2022.1060796
Perlegos, AE., Shields, EJ., Shen, H., Liu, KF., Bonini, NM. (2022). Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila. Nat Commun. 13(1), 5387. doi: 10.1038/s41467-022-33085-3
McGurk, L. et al. (2021). Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence. Hum Mol Genet. 30(19), 1797-1810. doi: 10.1093/hmg/ddab148
Byrns, CN., Saikumar, J., Bonini, NM. (2021). Glial AP1 is activated with aging and accelerated by traumatic brain injury. Nat Aging. 1(7), 585-597. doi: 10.1038/s43587-021-00072-0
Byrns, CN. & Bonini, NM. (2021). An Integrated Multi-omics Approach Identifies Therapeutic Potential for ATP6V1A in Late Onset Alzheimer’s Disease. Neuron. 109(2), 193-194. doi: 10.1016/j.neuron.2020.12.015
Saikumar, J., Kim, J., Byrns, CN., Hemphill, M., Meaney, DF., Bonini, NM. (2021). Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator. Nat Protoc. 16(1), 263-282. doi: 10.1038/s41596-020-00415-y
Saikumar, J., Byrns, CN., Hemphill, M., Meaney, DF., Bonini, NM. (2020). Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila. Proc Natl Acad Sci USA. 117(29), 17269-17277. doi: 10.1073/pnas.2003909117
McGurk, L., Rifai, OM., Bonini, NM. (2020). TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2. J Cell Sci. 133(12). doi: 10.1242/jcs.245811
Goodman, LD. & Bonini, NM. (2020). New Roles for Canonical Transcription Factors in Repeat Expansion Diseases. Trends Genet. 36, 81-92. doi: 10.1016/j.tig.2019.11.003
Goodman, LD. & Bonini, N. (2019). Repeat-associated non-AUG (RAN) translation mechanisms are running into focus for GGGGCC-repeat associated ALS/FTD. Prog Neurobiol. 183. doi: 10.1016/j.pneurobio.2019.101697
McGurk, L., Rifai, OM., Bonini, NM. (2019). Poly(ADP-Ribosylation) in Age-Related Neurological Disease. Trends Genet. 35, 601-613. doi: 10.1016/j.tig.2019.05.004
McGurk, L. et al. (2018). Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggration. Biochemistry 57, 6923-6926. doi: 10.1021/acs.biochem.8b00910
Chung, C.-Y. et al. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Nat Commun 9, 4406 (2018). doi: 10.1038/s41467-018-06543-0
Kennerdell, J., Liu, N. & Bonini, NM. MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging. Nat Commun 9,4188 (2018). doi: 10.1038/s41467-018-06592-5
McGurk et al. Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. Acta Neuropathologica Commun 6, 84 (2018). doi: 10.1186/s40478-018-0586-1
McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. 2018 Jul 26. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Mol Cell. doi:10.1016/j.molcel.2018.07.002.
Berson A, Nativio R, Berger SL, Bonini NM. 2018 Jun 6. Epigenetic Regulation in Neurodegenerative Diseases. Trends Neurosci. doi:10.1016/j.tins.2018.05.005.
Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, et al. 2018b. Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease. Nat Neurosci. 21(4):497–505. doi:10.1038/s41593-018-0101-9.
Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung C-Y, Garcia BA, Lee VM-Y, et al. 2017. TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Curr Biol. 27(23):3579–3590.e6. doi:10.1016/j.cub.2017.10.024.
Bonini NM, Berger SL. 2017. The Sustained Impact of Model Organisms-in Genetics and Epigenetics. Genetics. 205(1):1–4. doi:10.1534/genetics.116.187864.
Kramer NJ, Carlomagno Y, Zhang Y-J, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, et al. 2016. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science. 353(6300):708–712. doi:10.1126/science.aaf7791.
Burguete AS, Almeida S, Gao F-B, Kalb R, Akins MR, Bonini NM. 2015. GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function. Elife. 4:e08881. doi:10.7554/eLife.08881.
Perrimon N, Bonini NM, Dhillon P. 2016. Fruit flies on the front line: the translational impact of Drosophila. Dis Model Mech. 9(3):229–231. doi:10.1242/dmm.024810.
Feltzin VL, Khaladkar M, Abe M, Parisi M, Hendriks G-J, Kim J, Bonini NM. 2015. The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila. Aging Cell. 14(3):443–452. doi:10.1111/acel.12323.
McGurk L, Berson A, Bonini NM. 2015. Drosophila as an In Vivo Model for Human Neurodegenerative Disease. Genetics. 201(2):377–402. doi:10.1534/genetics.115.179457.
Soares L, Parisi M, Bonini NM. 2014. Axon injury and regeneration in the adult Drosophila. Sci Rep. 4:6199. doi:10.1038/srep06199.
Kim H-J, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM-Y, Finkbeiner S, Gitler AD, Bonini NM. 2014. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet. 46(2):152–160. doi:10.1038/ng.2853.
Fang Y, Soares L, Bonini NM. 2013. Design and implementation of in vivo imaging of neural injury responses in the adult Drosophila wing. Nat Protoc. 8(4):810–819. doi.org/10.1038/nprot.2013.042.
Liu N, Landreh M, Cao K, Abe M, Hendriks G-J, Kennerdell JR, Zhu Y, Wang L-S, Bonini NM. 2012. The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature. 482(7386):519–523. doi:10.1038/nature10810.
McGurk L, Bonini NM. 2011. Cell biology. Yeast informs Alzheimer’s disease. Science. 334(6060):1212–1213. doi:10.1126/science.1216073.
Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM-Y, Van Deerlin VM, et al. 2011. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. PLoS One. 6(3):e17951. doi:10.1371/journal.pone.0017951.
Lessing D, Bonini NM. 2009. Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants. Nat Rev Genet. 10(6):359–370. doi:10.1038/nrg2563.
Bilen J, Bonini NM. 2005. Drosophila as a model for human neurodegenerative disease. Annu Rev Genet. 39:153–171. doi:10.1146/annurev.genet.39.110304.095804.