2020s
Academia or Industry: Lessons on Choosing Career Paths─There May Be More Than One Fork in the Road Ahead Donna G. Blackmond, Marion Emmert, Donna M. Huryn, Michael L. Neidig, Thomas Schaub, Joseph J. Topczewski, Karla Bravo-Altamirano, Zachary Buchan, and Pablo J. Cabrera Organic Letters 2024 26 (14), 2682-2685 DOI: 10.1021/acs.orglett.4c01099
Replacement of the Hydroxamic Acid Group in the Selective HDAC8 Inhibitor PCI-34051, K. Long, D.A. Close, P.A. Johnston, D. M. Huryn Bioorganic & Medicinal Chemistry Letters, 2024, 108, 129810 DOI: https://doi.org/10.1016/j.bmcl.2024.129810
Empowering Women in Organic Chemistry (EWOC) at Five Years: Giving Back and Getting Back, E. Cantor, M. Faul, D. M. Huryn, L. Kallander, R. Ruck, M. Watson, J. Org. Chem. 2023, 88, 14257-14263 (+ 9 other ACS journals) 10.1021/acs.joc.3c02082
Optimization of 1,2,4-Triazole-based p97 Inhibitors for the Treatment of Cancer, M.G. LaPorte,C. Alverez,A. Chatterley,M. Kovaliov,E.J. Carder, M.J. Houghton, C. Lim, E.R. Miller, L. P. Samankumara,M. Liang,K. Kerrigan,Z. Yue,S. Li,F. Tomaino,F. Wang,N. Green,G. M. Stott,A.Srivastava,T.-F. Chou,P. Wipf, D.M. Huryn, ACS Med. Chem. Lett. 2023, 14, 977-985. 10.1021/acsmedchemlett.3c00163
Structure Property Relationships of Fluorinated Carboxylic Acid Bioisosteres, T. Alle, S. Joyasawal, K. Oukoloff, K. Long, Z. Owyang, K. Francisco, D. Cahard, D. M. Huryn, C. Ballatore, Bioorg. Med. Chem. Lett. 2023, 91, 129363. 10.1016/j.bmcl.2023.129363
Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury, K. Long, Z. Vaughn, M.D. McDaniels, S. Joyasawal, A. Przepiorski, E. Parasky, V. Sander, D. Cose, P.A. Johnston, A.J. Davidson, M. de Caestecker, N.A. Hukriede, D.M. Huryn, ACS Pharmacol. Transl. Sci. 2022, 5, 207-215. 10.1021/acsptsci.1c002430.
Affinity Capture with Small Molecule Bait for CryoEM: New Sample Preparation Method Reveals a 3.6Å Double-hexamer p97 Structure, M.R. Hoq, F.S. Vago, K. Li, M. Kovaliov, R.J. Nicholas, D.M. Huryn, P. Wipf, W. Jiang, D.H. Thompson, ACS Nano, 2021, 15, 8376-8385. 10.1021/acsnano.0c10185
Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia, M.G. Cotticelli, R. Forestieri, S. Xia, S. Joyasawal, T. Lee, K. Xu, A.B. Smith, D.M. Huryn, R.B. Wilson ACS Chemical Neurosciences, 2020, 11, 2535-2542. 10.1021/acschemneuro.0c00323
A Different Kind of Medicinal Chemistry Toolbox, D.M. Huryn, M.-L. Bolognesi, ACS Med. Chem. Lett. 2020, 3, 245-248. 10.1021/acsmedchemlett.9b00685
High-throughput Identification of Post-Transcriptional Utrophin Up-regulators for Duchenne Muscle Dystrophy (DMD) Therapy, E. Loro, K. Sengupta, S. Bogdanovich, K. Whig, D. Schultz, D.M. Huryn, T. Khurana, Sci. Rep. 2020, 10, 2132. 10.1038/s41598-020-58737-6
PTPRT Epigenetic Silencing Defines Lung Cancer with STAT3 Activation and Can Direct STAT3 Targeted Therapies, M. Sen, A. Kindsfather, L Danilova, F. Zhang, R. Colombo, M.G. LaPorte, B. Kurland, D.M. Huryn, P. Wipf, J.G. Herman, Epigenetics, 2020, 15, 604-617. 10.1080/15592294.2019.1676597
p97: An Emerging Target for Cancer, Neurogenerative Diseases and Viral Infections, D. M. Huryn, D.J.P. Kornfilt, P. Wipf, J. Med. Chem. 2020, 63, 1892-1907. 10.1021/acs.jmedchem.9b01318
2010s
Do Zebrafish Obey Lipinski Rules? K. Long, S.J. Kostman, C. Fernandez, J.C. Burnett, D.M. Huryn, ACS Med. Chem. Lett. 2019, 10, 1002-1006. 10.1021/acsmedchemlett.9b00063
Ferroptosis as a Novel Therapeutic Target for Friedreich’s Ataxia, M.G. Cotticelli, S. Xia, D. Lin, T. Lee. L. Terrab, P. Wipf, D.M. Huryn, R.B Wilson, J. Pharmacol. Exp. Ther. 2019, 369, 47-54. 10.1124/jpet.118.252759
Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase, p97, M.G. LaPorte, J.C. Burnett, R. Colombo, S.L. Bulfer, C. Alverez, T.-F. Chou, R.J. Neitz, N. Green, W.J. Moore, Z. Yue, S. Li, M.R. Arkin, P. Wipf, D.M. Huryn. ACS Med. Chem. Lett. 2018, 9, 1075-1081. 10.1021/acsmedchemlett.8b00372
Medicinal Chemistry: Where are All the Women? D.M. Huryn, M.L. Bolognesi, W.B. Young, ACS Med Chem. Lett. 2017, 8, 900-902. 10.1021/acsmedchemlett.7b00321
Mechanism of Action of Selective Inhibitors of IL-6 induced STAT3 Pathway in Head and Neck Cancer Cell Lines, M. Sen, P.A. Johnston, N.I. Pollock, K. DeGrave, S.C. Joyce, M.L Freilino, D.M. Huryn, P. Wipf, J.R. Grandis, J. Chem. Biol. 2017, 10, 129-141. 10.1007/s12154-017-0169-9
A Threonine Turnstile Defines a Dynamic Amphiphilic Binding Motif in the AAA ATPase p97 Allosteric Binding Site, J.C. Burnett, C. Lim, B.D. Peyser, L.P. Samankumara, M. Kovaliov, R. Colombo, S.L. Bulfer, M.G LaPorte, A.R. Hermone, C.F McGrath, M.R Arkin, R. Gussio D.M. Huryn, P. Wipf Org. Biomol. Chem. 2017, 15, 409-4114. 10.1039/c7ob00526a
Toxicity, Pharmacokinetics and Metabolism of a Novel Inhibitor of IL-6-induced STAT3 Activation, B. Kiesel, R. Parise, J. Guo, D. Huryn, P. Johnston, R. Colombo, M. Sen, J. Grandis, J. Beumer, J. Eiseman, Cancer Chemother. Pharmacol. 2016, 78, 1225-1235. 10.1007/s00280-016-3181-9
Optimization of Pyrazole-containing 1,2,4-Triazolo-[3,4-b]thiadiazines, a New class of STAT3 Pathway Inhibitors, M.G. LaPorte, Z. Wang, R. Colombo, A. Garzan, V.A. Peshkov, M.Liang, P.A. Johnston, M.E. Schurdak, M. Sen, D.P. Camarco, Y. Hua, N.I. Pollock, J.S. Lazo, J.R. Grandis, P. Wipf, D. M. Huryn, Bioorg. Med. Chem. Lett. 2016, 26, 3581-3585. 10.1016/j.bmcl.2016.06.017
Development and Implementation of a High-throughput High-content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells, P.A. Johnston, M.M. Nguyen, J.A. Dar, J. Ai, Y. Wang, K.Z. Masoodi, T. Shun, S. Shinde, D.P. Camarco, Y. Hua, D.M. Huryn, G.M. Wilson, J.S. Lazo, J.B. Nelson, P. Wipf, Z. Wang, Assay Drug Dev. Technol. 2016, 14, 226-239. 10.1089/adt.2016.716
Structure Property Relationships of Carboxylic Acid Isosteres, P. Lassalas, B. Ga, C. Lasfargeas, M.J. James, A.B. Smith III, D.M. Huryn, C. Ballatore, J. Med. Chem. 2016, 59, 3183-3203. 10.1021/acs.jmedchem.5b01963
2.3Å Resolution Cryo-EM Structure of Human p97 and Mechanism of Allosteric Inhibition, S. Banerjee, A. Bartesachi, A. Merk, P. Rao, S.L. Bulfer, Y. Yan, N. Green, B. Mroczkowski, P. Wipf, V. Falconieri, R.J. Deshaies, J.L.S. Milne, D.M. Huryn, M. Arkin, S. Subramanian, Science 2016, 351, 871-875. 10.1126/science.aad7974
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway, C. Alverez, S. Bulfer, R. Chakrasali, M. Chimenti, R.J. Deshaies, N. Green, M. Kelly, M.G. LaPorte, T. Lewis, M. Liang, W.J. Moore, R.J. Neitz, V. Peshkov, M. Walters, F. Zhang, M. Arkin, P. Wipf, D.M. Huryn, ACS Med. Chem Lett. 2016, 7, 182-187. 10.1021/acsmedchemlett.5b00396
Delayed Treatment with PTBA Analogs Reduces Post Injury Renal Fibrosis after Kidney Injury, N. Skrypnyk, S. Subramanian, L. Brilli-Skvarca, T. Novitskaya, C. Woods, T.K. Chiba, T. Patel, N. Goldberg. L. McDermott, P.N. Vinson, M.W. Calcutt, D.M. Huryn, L.A. Vernetti, A. Vogt, N. Hukriede, M. deCaestecker, AJP Renal Physiol. 2016, 310, F705-F716. 10.1152/ajprenal.00503.2015
Structure-Activity Relationship of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97, C. Alverez, M.R. Arkin, S.L. Bulfer, R. Colombo, M. Kovaliov, M.G. LaPorte, C. Lim, M. Liang, W.J. Moore, R. J. Neitz, Y. Yan, Z. Yue, D.M. Huryn, P. Wipf ACS Med. Chem. Lett. 2015, 6, 1225-1230. 10.1021/acsmedchemlett.5b00364
HCS Campaign to Identify Selective Inhibitors of IL-6-induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines, P.A. Johnston, M. Sen, Y. Hua, D. Camarco, T. Y. Shun, J.S. Lazo, G. Mustata Wilson, L.O. Resnick, M.G. LaPorte, P. Wipf, D.M. Huryn, J.R. Grandis, Assay Drug Dev. Tech. 2015, 13, 356-376. 10.1089/adt.2015.663