21st Annual Lecture
Head of Science, Chan Zuckerberg Initiative
Torsten N. Wiesel Professor, The Rockefeller University
Friday, April 19, 2019
Rainey Auditorium, Penn Museum
3620 South Street (Trescher Entrance)
Organizing behavior across timescales
Genes, neurons, and circuits encode information, interpret it based on context and motivational states, and use that combined input to drive flexible behaviors. Understanding how these processes propagate across temporal and spatial scales is daunting in the complex human brain, but more straightforward in the simple brain of the nematode C. elegans. Our studies of C. elegans foraging behaviors have provided insights into three levels of behavioral regulation: the gating of information flow by circuit state over seconds, the extrasynaptic regulation of circuits by neuropeptides and neuromodulators over minutes and hours, and innate programs that modify behavior across development.