Abstract: “Rising human exposure to pathogens couples with increased antibiotic resistance and slow antibiotic development to pose a nearly insurmountable human health challenge. My work aims to discover novel proteins critical for pathogen survival, reveal important insights into their mechanisms, and develop chemical tools to modulate them. By focusing on pathogens with limited biosynthetic capabilities, we aim to discover novel antibiotic targets that are less likely to evade inhibitors. This talk will describe our use of traditional approaches and our development of new methods to accelerate the proteome-wide discovery of critical metabolite handling proteins in human pathogens.”
Inquiries: nguyeny@sas.upenn.edu