Title: What makes an energy landscape optimally searchable?
Abstract: The energy landscape of molecules, such as proteins, is high dimensional and rough, dominated by numerous metastable states. Consequently, performing a random search that visits every single possible conformation would require cosmological times to reach the global energy minimum. Nevertheless, in functional bio-molecules, the relaxation time to the native state is relatively fast. Here we will investigate what are the landscape’s architectural features that promote search efficiency.