Significant Publications
The complete list of Professor Smith’s publications are displayed in reverse chronological order. A search engine allows for searches by the first or last name of authors, keywords in the title and abstract.
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| Amos B. Smith, III
Full Publication List [H-index-96] Major Recent Publications on Total Synthesis |
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| 804. | J. Ding, A. B. Smith, III, Total Synthesis of the Reported Structure of Neaumycin G, J. Am. Chem. Soc. https://doi.org/10.1021/jacs.3c06573. 2023 |
| 788. | J. B. Cox, A. A. Kellum, Y. Zhang, B. Li, A. B. Smith. III. Total Synthesis of (-)-Bastimolide A. A Show Case for Type I Anion Relay Chemistry, Angew. Chem. Int. Ed. 2022, e202204884. |
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Important Publications on AIDS Research |
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| 800. | C. Fritschi, S. Anang, Z. Gong, M. Mohammadi, J. Richard, C. Bourassa, K. Severino, H. Richter, D. Yang, H-C. Chen, T-J. Chiu, M. Seaman, N. Mandani, C. Abrams, A. Finzi, W.A. Hendrickson, J. Sodroski, A.B. Smith, III. Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity. PNAS. 2023, 120, 13, e2222073120. |
| 801. | S. Ding, W. D. Tolbert, H. Zhu, D. Lee, T. Higgins, X. Zhao, D. Nguyen, R. Sherburn, J. Richard, G.-G. Lepage, H. Medjahed, M. Mohammadi, C. Abrams, M. Pazgier, A. B. Smith III, A. Finzi, Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC. Viruses 2023, 15, 1185. |
| 798. | Richard, J. Provost, C Bourassa. N. Brassard, G. Goyette, H. Medjahed, G. Gendron-Lepage, F. Gaudette, H.-C. Chen, W.D. Tobert, A. B. Smith, III, M. Pazgier, M. Dube, A. Clark, W. Mothers, D. E. Kaufmann, A. Finzi. Temsavir Blocks HIV-1 Soluble gp120-Induced Immunomodulartory Activity, Cell Rep. Med. |
| 661. | J. Courter, N. Mandani, J. Sodroski, A. Schon, E. Freire, P. D. Kwong, W.A. Hendrickson, I.M. Chaiken, J.M. LaLonde, and A.B. Smith, III. Structure-Based Design, Synthesis and Validation of CD-4 Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist. Acc. Chem. Res. 2014, 47, 1228-1237 |
| Major Accounts of Chemical Research Articles | |
| 759. | Y. Deng, A. B. Smith, III. Evolution of the Anion Relay Chemistry: Construction of Architecturally Complex Natural Products. Acc. Chem. Re. 2020, 53(4), 988–1000. |
| 600. | A. B. Smith, III, A. K. Charnley and R. Hirschmann. Pyrrolinone-Based Peptidomimetics. “Let the Enzyme or Receptor be the Judge”. Acc. Chem. Res. 2011, 44, 180-193. |
| 566. | R. F. Hirschmann, K. C. Nicolaou, A. R. Angeles, J. S. Chen, and A. B. Smith, III. The b-D-Glucose Scaffold as a b-Turn Mimetic. Acc. Chem. Res. 2009, 42, 1511-1520. |
| 538. | A. B. Smith, III, R. J. Fox, and T. M. Razler. Evolution of the Petasis-Ferrier Union/Rearrangement Tactic: Construction of Architecturally Complex Natural Products Possessing the Ubiquitous cis-2,6-Substituted Tetrahydropyran Structural Element. Acc. Chem. Res. 2008, 41, 675-687. |
| 464. | A. B. Smith, III, and C. M. Adams. Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products. Acc. of Chem. Res. 2004, 37, 365-377. |
| 354. | Smith, Amos B., III; Condon, Stephen M.; McCauley, John A. Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and s-Bond Olefin Constructions. Accounts of Chemical Research (1998), 31(1), 35-46. |
| 213. | J. E. Fischer, P. A. Heiney, and A. B. Smith, III, “Solid State Chemistry of Fullerene-Based Materials,” Acc. Chem. Res., 25, 112-118 (1992). |
| Total Synthesis / New Synthetic Methods | |
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| 789. | R. Bai, A. B. Smith, III, George R. Pettit, E. Hamel. The Interaction of Spongistatin 1 with Tubulin, Arch. Biochem. Biophys. 727 2022 109296. |
| 773. | Y. Deng, C-P. H. Yang, and A. B. Smith, III. Enantioselective Total Synthesis of (+)-Peniciketals A and B: Two Architecturally Complex Spiroketals. J. Am. Chem. Soc. 2021,143,1740-1744. |
| 771. | K. T. O’Brien, J. Nadraws and A. B. Smith, III. A New Difluoromethylene Lynchpin/Synthon. Application in Conjunction with Anion Relay Chemistry (ARC) Permits Ready Access to Diverse Difluoromethylene Scaffolds. Org. Lett. 2021, 23,1521-1954. |
| 769. | Y. Chen, X. Zhang, F. Liu, G. He, J. Zhang, K. N. Houk, A. B. Smith, III, and Y. Liang. The Role of Cul in the Siloxane-Meditated Pd-Catalyzed Cross-Coupling Reactions of Aryl Iodides with Aryl Lithium Reagents: A DFT Analysis. Chinese Chem Lett. 2020. |
| 763. | G. Sarikaki, N. Chistoforidou, N. Gaboriaud-Kolar, A. B. Smith, III, I. K. Kostakis, A-L. Skaltsounis. A Biomimetic Synthesis of Olecanthal, Oleacein and Their Analogues Starting from Oleuropein, A Major Compound of Olive Leaves. Journal of Natural Products. 2020. |
| 759. | Y. Deng, A. B. Smith, III. Evolution of the Anion Relay Chemistry: Construction of Architecturally Complex Natural Products. Accounts of Chemical Research. 2020, 53, 988-1000. |
| 756. | J. Chen, J. Park, S. M. Kirk, H-C. Chen, X. Li, D. J. Lippincott, B. Melillo, and A. B. Smith, III. Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-Trifluoroacetate Salt. Org. Process Res. Dev. 2019, 23, 2464-2469. |
| 755. | D. Deng, M. D. Nguyen, Y. Zou, K. N. Houk, A. B. Smith, III. Generation of Dithianyl and Dioxolanyl Radicals Using Photoredox Catalysis: Application in the Total Synthesis of the Danshenspiroketallactones via Radical Relay Chemistry. Org. Lett. 2019, 21,1708-1712. |
| 752. | K. T. O’Brien and A. B. Smith, III. Merging Asymmetric [1,2]-Additions of Lithium Acetylides to Carbonyls with Type II Anion Relay Chemistry (ARC). Org. Lett. 2019, 21, 7655-7659. |
| 750. | Y. Zou, X.-S. Xue, Y. Deng, A. B. Smith, III, and K. N. Houk. Factors Controlling Reactivity in the Hydrogen Atom Transfer and Radical Addition Steps of A Radical Relay Cascade. Org. Lett. 2019, 21, 5894-5897. |
| 742. | Y. Zou, X. Li, Y. Yang, S. Berritt, J. Melvin, S. Gonzales, M. Spafford, and A. B. Smith, III. Total Synthesis of (–)-Nodulisporic Acids D, C and B: Evolution of a Synthetic Strategy. J. Am. Chem. Soc. 2018, 140 (30), 9502-9511. |
| 735. | M. H. Nguyen, M. Imanishi, T. Kurogi, X. Wan, J. E. Ishmael, K. L. McPhail and A. B. Smith III. Synthetic Access to the Mandelide Family of Macrolides: Development of an Anion Relay Chemistry Strategy. J. Org. Chem. 2018, 83, 4287-4306. |
| 729. | Y. Zou and A. B. Smith, III. Total Synthesis of Architecturally Complex Indole Terpenoids: Strategic and Tactical Evolution. J. Antibiotics. 2018, 71, 185-204. |
| 725. | Q. Liu, Y. Deng, and A. B. Smith III. Total Synthesis of (–)-Nahuoic Acid Ci (Bii). J. Am. Chem. Soc. 2017, 82, 1156-11071. |
| 723. | Y. Deng, Q. Liu and A. B. Smith, III. Oxidative [1,2]-Brook Rearrangements Exploiting Single-Electron Transfer: Photoredox-Catalyzed Alkylations and Arylations. J. Am. Chem. Soc. 2017, 139, 9487-9490. |
| 722. | M. Nguyen. K. T. O’Brien and A. B. Smith, III. Design, Synthesis and Application of Polymer-Supported Silicon Transfer Agents for Cross-Coupling Reactions with Organolithium Reagents. J. Org. Chem. 2017, 82, 11056-11071. |
| 715. | Q. Liu, Y. Chen, X. Zhang, K. N. Houk and A. B. Smith, III. Type II Anion Relay Chemistry: Conformational Constraints to Achieve Effective [1,5]-Vinyl Brook Rearrangements. J. Am. Chem. Soc. 2017, 139, 8710-8717. |
| 695. | Q. Liu, C. An, K. TenDyke, H. Cheng, Y. Y. Shen, A. T. Hoye and A. B. Smith, III. Design, Synthesis, and Evaluation of Ircinastatin Analogues: Simplification of the Tetrahydropyran Core and C(11) Substituents. J. Org. Chem. 2016, 81, 1930-1942. |
| 693. | M. H. Nguyen, M. Imanishi, T. Kurogi and A. B. Smith, III. Total Synthesis of (–)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol. J. Am. Chem. Soc. 2016. 11, 3675-3678. |
| 689. | D. Martinez-Solorio, B. Melillo, L. Sanchez, Y. Liang, E. Lam, K. N. Houk and A. B. Smith, III. Design, Synthesis and Validation of an Effective, Reusable Silicon-Based Transfer Agent for Room-Temperature Pd-Catalyzed Cross-Coupling Reactions of Aryl and HeteroAryl Chlorides with Readily Available Aryl Lithium Reagents. J. Am. Chem. Soc. 2016, 138, 1836-1839. |
| 688. | M. Farrell, B. Melillo, and A. B. Smith, III. Type II Anion Relay Chemistry: Exploiting Bifunctional Weinreb Amide Linchpins for the One-Pot Synthesis of Differentiated 1,3-Diketones, Pyrans and Spiroketals. Angew. Chem. Int. Ed. 2016, 55, 232-235. |
| 683. | Y. Ai, M. V. Kozytska, Y. Zou, A. S. Khartulyari and A. B. Smith, III. Total Synthesis of (–)-Enigmazole A. J. Am. Chem. Soc. 2015, 137, 15426-15429. (Also see: E. Carreira, M. Westphal, Synfacts 2016, 12, 0117.) https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0035-1561117.pdf |
| 681. | A. M. Hunter and A. B. Smith, III. Editorial; Review of Supporting Information at Organic Letters. Org. Lett., 2015, 17, 2867-2869 (Not NIH Funded). |
| 678. | Y. Zou, J. E. Melvin, S. S. Gonzales and A. B. Smith, III. Total Synthesis of (–)-Nodulisporic Acid. J. Am. Chem. Soc. 2015, 137, 7095-7098. |
| 677. | A. Sokolsky, M. Cattoen and A. B. Smith, III. Synthesis of a C(1)-C(23) Fragment for Spirastrellolide E: Development of a Mechanistic Rationale for Spiroketalization. Org. Lett. 2015, 17, 1898-1901. |
| 671. | A. Shvartsbart and A. B. Smith, III. The Daphniphyllum Alkaloids: Total Synthesis of (−)-Calyciphylline N. J. Am. Chem. Soc. 2015, 137, 3510-3519. |
| 670. | A. Sokolsky, X. Wang and A. B. Smith, III. Spirastrellolide E: Synthesis of an advanced C(1)-C(24) southern hemisphere. Tet. Lett. 2015, 56, 3160-3164. |
| 666. | B. D. Williams and A. B. Smith, III. Total Synthesis of (+)-18-epi-Latrunculol A: Development of a Synthetic Route. J. Org. Chem. 2014, 79, 9284-9296. |
| 658. | M. H. Nguyen and A. B. Smith, III. Recyclable Polystyrene-Supported Siloxane-Transfer Agent for Palladium-Catalyzed Cross-Coupling Reactions. Org. Lett. 2014, 16, 2070-2073. |
| 655. | M. Z. Chen, O. Gutierrez and A. B. Smith, III. Through-Bond/Through-Space Anion Relay Chemistry Exploiting Vinylepoxides as Bifunctional Linchpins. Angew. Chem. Int. Ed. 2014, 53, 1279-1282. |
| 654. | A. Shvartsbart and A. B. Smith, III. Total Synthesis of (−)-Calyciphylline N. J. Am. Chem. Soc. 2014, 136, 870-873. |
| 649. | M. H. Nguyen and A. B. Smith, III. Copper-Catalyzed Electrophillic Amination of Organolithium Compounds Mediated by Recoverable Siloxane Transfer Agents. Org. Lett. 2013, 15, 4872-4875. |
| 647. | B. D. Williams and A. B. Smith, III. Total Synthesis of (+)-18-epi-Latrunculol A. Org. Lett. 2013, 15, 4584-4587. |
| 645. | M. H. Nguyen and A. B. Smith, III. Polymer-Supported Siloxane Transfer Agents for Pd-Catalyzed Cross-Coupling Reactions. Org. Lett. 2013, 15, 4258-4261. |
| 641. | D. Martinez-Solorio, A. T. Hoye, M. H. Nguyen, and A. B. Smith, III. The Design, Synthesis and Validation of Recoverable and Readily Reusable Siloxane Transfer Agents for Pd-Catalyzed Cross-Coupling Reactions. Org. Lett. 2013, 15, 2454-2457. |
| 640. | B. Melillo and A. B. Smith, III. A Unified Synthetic Strategy to the Cryptocarya Family of Natural Products Exploiting Anion Relay Chemistry (ARC). Org. Lett. 2013, 15, 2282-2285. |
| 639. | C. An, J. A. Jurica, S. P. Walsh, A. T. Hoye and A. B. Smith, III. Total Synthesis of (+)-Irciniastatin A (aka Pysmberin) and (-)-Irciniastatin B. J. Org. Chem. 2013, 78, 4278-4296. |
| 633. | G. L. Adams and A. B. Smith, III. Access to the Akuammiline Family of Alkaloids: Total Synthesis of (+)-Scholarisine A. J. Am. Chem. Soc. 2013, 135, 519-528. |
| 627. | A. Sokolsky and A. B. Smith, III. Validation of Diethoxy-phosphonate as an Effective Agent for Charge Transfer in Anion Relay Chemistry (ARC). Org. Lett. 2012, 14, 4470-4473. |
| 626. | C. An, A. T. Hoye and A. B. Smith, III. Total Synthesis of (−)-Irciniastatin B and Structural Confirmation via Chemical Conversion to (+)-Irciniastatin A (Psymberin). Org. Lett. 2012, 14, 4350-4353. |
| 625. | X. Wang, T. J. Paxton, N. Li and A. B. Smith, III. Spirastrellolide B: Construction of the C(26)-C(40) Northern Hemisphere and a Related [5,5,7]-Bis-Spiroketal Analogue. Org. Lett. 2012, 14, 3998-4001. |
| 617. | A. B. Smith, III, A. T. Hoye, D. Martinez-Solorio, W.-S. Kim and R. Tong. Unification of Anion Relay Chemistry (ARC) with the Takeda and Hiyama Cross-Coupling Reactions: Identification of an Effective Silicon-Based Transfer Agent. J. Am. Chem. Soc. 2012 134, 4533–4536. |
| 616. | G. L. Adams, P. J. Carroll and A. B. Smith, III. Total Synthesis of (+)-Scholarisine A. J. Am. Chem. Soc. 2012 134, 4037-4040. |
| 612. | A. B. Smith, III, S. Dong, R. J. Fox, J. B. Brenneman, J. A. Vanecko and T. Maegawa. (+)-Sorangicin A; Evolution of a Viable Synthetic Strategy. Tetrahedron 2011, 67, 9809-9828. |
| 610. | A. B. Smith, III, O. Atasoylu, K. Sugawara, S. Horwitz. Design and Synthesis of (+)-Discodermolide-Paclitaxel Hybrids Leading to Enhanced Biological Activity. J. Med. Chem. 2011, 54, 6319-6327. |
| 609. | A. B. Smith, III, C. Risatti, O. Atasoylu, C. S. Bennett, J. Liu, H. Cheng, K. TenDyke, Q. Xu. Design, Synthesis and Biological Evaluation of Diminutive Forms of (+)-Spongistatin I: Lessons Learned. J. Am. Chem. Soc. 2011, 133, 14042-14053. |
| 608. | A. B. Smith, III, R. Tong, W.-S. Kim and W. A. Maio. Anion Relay Chemistry: Access to the Type II Reaction Manifold via a Fundamental Different Reaction Pathway Exploiting 1-Oxa-2-Silacyclopentanes and Related Congeners. Angew. Chem. Int. Ed. 2011, 50, 8904-8907. |
| 605. | A. B. Smith, III, H. Han and W.-S. Kim. Diversity-Oriented Synthesis of 2,4,6-trisubstituted Piperidines via Type II Anion Relay Chemistry (ARC). Org. Lett. 2011, 13, 3328-3331. |
| 602. | A. B. Smith, III, A.-M. Hogan, Z. Liu, T. M. Razler, R. M. Meis, B. I. Morinaka and T. F. Molinski. Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues. Tetrahedron 2011, 67, 5069-5078. PMC3146768 |
| 601. | A. B. Smith, III and W.-S. Kim. Diversity Oriented Synthesis Leads to a New Class of Bi-functional Linchpins Uniting Anion Relay Chemistry (ARC) with Benzyne Reactivity. Proc. Nat. Acad. Sci. 2011, 108, 6787-6792. PMC3084103. |
| 600. | A. B. Smith, III, A. K. Charnley and R. Hirschmann. Pyrrolinone-Based Peptidomimetics. “Let the Enzyme or Receptor be the Judge”. Acc. Chem. Res. 2011, 44, 180-193. |
| 581. | A. B. Smith, III, C. A. Risatti, O. Atasoylu, C. S. Bennett, K. TenDyke and Q. Xu. Design, Synthesis and Biological Evaluation of EF- and ABEF- Analogs of (+)-Spongistatin 1. Org. Lett. 2010, 12, 1792-1795. PMC2853872. |
| 580. | O. Atasoylu, G. Furst, C. Risatti and A. B. Smith, III. The Solution Structure of (+)-Spongistatin 1 in DMSO. Org. Lett. 2010, 12, 1788-1791. PMC2856070. |
| 563. | A. B. Smith, III, S. Dong, J. B. Brenneman and R. J. Fox. Total Synthesis of (+)-Sorangicin A. J. Am. Chem. Soc., 2009, 131, 12109-12111. PMC2749982. |
| 553. | A. B. Smith, III, T. Bosanac, and K. Basu. Evolution of the Total Synthesis of (−)-Okilactomycin Exploiting a Tandem Oxy-Cope Rearrangement/Oxidation, a Petasis-Ferrier Union/Rearrangement, and Ring-Closing Metathesis. J. Am. Chem. Soc. 2009, 131, 2348-2358. PMC2697663. |
| 547. | A. B. Smith, III and W. M. Wuest. Evolution of Multi-Component Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products. Chem. Comm. 2008, 5883-5895. PMC2769507. |
| 546. | D. C. Beshore and A. B. Smith, III. The Lyconadins: Enantioselective Total Synthesis of (+)-Lyconadin A and (−)-Lyconadin B. J. Am. Chem. Soc. 2008, 130, 13778-13789. PMC2819465. |
| 544. | A. B. Smith, III, W. S. Kim and W. M. Wuest. Ortho-TMS Benzaldehyde: An Effective Linchpin for Type II Anion Relay Chemistry. Angew. Chem. Int. Ed. 2008, 47, 7082-7086. PMC2756143. |
| 528. | A. B. Smith, III and D. Lee. Total Synthesis of (+)- Tedanolide. J. Am. Chem. Soc. 2007, 129, 10957-10962. |
| 514. | A. B. Smith, III, M. Xian, and W.-S. Kim. The [1,5]-Brook Rearrangement: An Initial Application in Anion Relay Chemistry. J. Am. Chem. Soc. 2006, 128, 12368-12369. |
| 503. | A. B. Smith, III and M. Xian. Anion Relay Chemistry: An Effective Tactic for Diversity Oriented Synthesis. J. Am. Chem. Soc. 2006, 128, 66-67. |
| 490. | G. Beauchamp, R. Keast, D. Morel, J. Lin, J. Pika, Q. Han, C.-H. Lee, A. B. Smith, III, and P. Breslin. Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature 2005, 437, 45-46. |
| 480. | A. B. Smith, III, E. F. Mesaros, and E. A. Meyer. Total Synthesis of (–)-Kendomycin Exploiting a Petasis-Ferrier Rearrangement/Ring-Closing Olefin Metathesis Strategy. J. Am. Chem. Soc. 2005, 127, 6948-6949. |
| 468. | A. B. Smith, III, C. M. Adams, S. A. Lodise-Barbosa, and A. P. Degnan. A unified approach to the tedanolides: total synthesis of (+)-13-deoxytedanolide. Proc. Natl. Acad. Sci. USA 2004, 101, 12042-12047. |
| 464. | A. B. Smith, III, and C. M. Adams. Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products. Acc. of Chem. Res. 2004, 37, 365-377. |
| 446. | A. B. Smith, III, N. Kanoh, H. lshiyama, N. Minakawa, J. D. Rainier, R. A. Hark, Y. S. Cho, H. Cui, and W. M. Moser. Tremorgenic lndole Alkaloids. The Total Synthesis of (–) Penitrem D. J. Am. Chem. Soc. 2003, 125, 8228-8237. |
| 439. | Smith, Amos B.; Adams, Christopher M.; Barbosa, Stephanie A. Lodise; Degnan, Andrew P. Total Synthesis of (+)-13-Deoxytedanolide. Journal of the American Chemical Society (2003), 125(2), 350-351. |
| 434. | Smith, Amos B.; Safonov, Igor G.; Corbett, R. Michael. Total Syntheses of (+)-Zampanolide and (+)-Dactylolide Exploiting a Unified Strategy. Journal of the American Chemical Society (2002), 124(37), 11102-11113. |
| 420. | Smith, Amos B., III; Minbiole, Kevin P.; Verhoest, Patrick R.; Schelhaas, Michael. Total synthesis of (+)-phorboxazole A exploiting the Petasis-Ferrier rearrangement. Journal of the American Chemical Society (2001), 123(44), 10942-10953. |
| 417. | Smith, Amos B., III; Adams, Christopher M.; Kozmin, Sergey A.; Paone, Daniel V. Total Synthesis of (-)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction. Journal of the American Chemical Society (2001), 123(25), 5925-5937. |
| 410. | Smith, Amos B., III; Lin, Qiyan; Doughty, Victoria A.; Zhuang, Linghang; McBriar, Mark D.; Kerns, Jeffrey K.; Brook, Christopher S.; Murase, Noriaki; Nakayama, Kiyoshi. The spongistatins: architecturally complex natural products. Part two. Synthesis of the C(29-51) subunit, fragment assembly, and final elaboration to (+)-spongistatin 2. Angewandte Chemie, International Edition (2001), 40(1), 196-199. |
| 403. | Smith, Amos B., III; Kanoh, Naoki; Ishiyama, Haruaki; Hartz, Richard A. Total Synthesis of (-)-Penitrem D. Journal of the American Chemical Society (2000), 122(45), 11254-11255. |
| 384. | Smith, Amos B., III; Friestad, Gregory K.; Barbosa, Joseph; Bertounesque, Emmanuel; Duan, James J.-W.; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Spoors, P. Grant; Salvatore, Brian A. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B: Cyanotetraene Construction, Asymmetric Synthesis of the C(26-37) Oxazole, Fragment Assembly, and Final Elaboration. Journal of the American Chemical Society (1999), 121(45), 10478-10486. |
| 359. | Smith, Amos B., III; Ott, Gregory R. Total Syntheses of (-)-Macrolactin A, (+)-Macrolactin E, and (-)-Macrolactinic Acid: An Exercise in Stille Cross-Coupling Chemistry. Journal of the American Chemical Society (1998), 120(16), 3935-3948. |
| 354. | Smith, Amos B., III; Condon, Stephen M.; McCauley, John A. Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and s-Bond Olefin Constructions. Accounts of Chemical Research (1998), 31(1), 35-46. |
| 337. | Smith, Amos B., III; Condon, Stephen M.; McCauley, John A.; Leazer, Johnnie L., Jr.; Leahy, James W.; Maleczka, Robert E. A Unified Total Synthesis of the Immunomodulators (-)-Rapamycin and (-)-27-Demethoxyrapamycin: Assembly of the Common C(1-20) Perimeter and Final Elaboration. Journal of the American Chemical Society (1997), 119(5), 962-973. |
| 323. | Nagamitsu, Tohru; Sunazuka, Toshiaki; Tanaka, Haruo; Omura, Satoshi; Sprengeler, Paul A.; Smith, Amos B., III. Total Synthesis of (+)-Lactacystin. Journal of the American Chemical Society (1996), 118(15), 3584-90. |
| 225. | Smith, Amos B., III; Rano, Thomas A.; Chida, Noritaka; Sulikowski, Gary A.; Wood, John L. Total synthesis of the cytotoxic macrocycle (+)-hitachimycin. Journal of the American Chemical Society (1992), 114 (21), 8008-22. |
| 216. | Smith, Amos B., III; Leahy, James W.; Noda, Ichio; Remiszewski, Stacy W.; Liverton, Nigel J.; Zibuck, Regina. Total synthesis of the latrunculins. Journal of the American Chemical Society (1992), 114 (8), 2995-3007. |
| 183. | Smith, Amos B.,III; Hale, Karl J.; Vaccaro, Henry A.; Rivero, Ralph A. Phyllanthoside-phyllanthostatin synthetic studies. 9. Total syntheses of (-)-phyllanthostatin 1, (+)-phyllanthostatin 2, and (+)-phyllanthostatin 3. Journal of the American Chemical Society (1991), 113 (6), 2112-22. |
| 118. | Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.; Smith, Amos B., III. Milbemycin-avermectin studies. 5. Total synthesis of milbemycin b3 and its C(12) epimer. Journal of the American Chemical Society (1986), 108 (10), 2662-74. |
| AIDS Research (2003-Present) | |
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| 778. | J. K. Rajashekar, J. Richard, J. Beloor, J. Prevost, S. P. Anand, L. Shan, D. Hemdler-Brandstetter, G. Gendron-Lepage, H. Medjahed, F. Gaudette, I. Ullah, A. Peric, D. E. Kaufmann, J. Sodroski, M. Pazgier, R. A. Flavell, J. Park, H.-C. Chen, A. B. Smith, III, A. Finzi, P. Kumar. Modulating the HIV-1 Envelope Glycoprotein Conformation to Decrease the HIV-1 Reservoir. Cell Host & Microbe 2021, 29, 1-13. |
| 775. | A. Gaffney A. Nangarlia, C. Ang, S. Gossert, A.A. Rashad, M. A. Hossain, C. F. Abrams. A. B. Smith, IIII, I Chaiken. HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates. ACS Chem. Bio. 2021, 16, 193-204. |
| 772. | D. Vezina, S.Y. Gong, W. Tolbert, S. Ding, D. Nguyen, G. Gendron-Lepage, B. Melillo, A. B. Smith, III, M. Pazgier and A. Finzi, Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation. J. Virol. 2021, 95, 5, e01620-20. |
| 770. | C. A. Jette, C. O. Barnes, S. M. Kirk, B. Melillo, A. B. Smith, III, P. J. Bjorkman. Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nat. Commun., 2021, 12, 1950. |
| 766. | A. Laumaea, A. B. Smith, III, J. Sodroski, A. Finzi. Opening the HIV Envelope: Potential of CD4 Mimics as Multifunctional HIV Entry Inhibitors. Curr. Opin. HIV AIDS. 2020, 15, 300-308. |
| 764. | G. Beaudoin-Bussieres, J. Prevost, G. Gendron-Lepage, B. Melillo, J. Chen, A. B. Smith, III, M. Pazgier, and A. Finzi. Elicitation of Cluster A and Co-Receptor Binding Site Antibodies are Reuired to Eliminate HIV-1 Infected Cells. Microorganisms 2020 8(5) 710 doi: 10.3390/microorganisms 8050710. |
| 762. | J. Prevost, W. D. Tolbert, H. Medjahed, R. T. Sherburn, N. Madani, D. Zoubchenok, G. Gendron-Lepage, A. E. Gaffney, M. C. Grenier, S. Kirk, N. Vergara, C. Han, B. T. Mann, A. L. Chenine, A. Ahmed, I. Chaiken, F. Kirchhoff, B. Hahn, H. Haim, C. Abrams, A. B. Smith, III, J. Sodroski, M. Pazgier, A. Finzi. The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity. mBio.asm.org. 2020, 11 (3), e00280-20. |
| 761. | M. Lu, X. Ma, N. Reichard, D. S. Terry, J. Arthos, A. B. Smith, III, J. G. Sodroski, S. C. Blanchard, W. Mothes. Shedding-Resistant HIV-1 Envelope Glycoproteins that Remain Responsive to Conformation-Prefering Ligands. J. Virol. 2020. |
| 760. | S. Zou, S. Zhang, A. Gaffney, H. Ding, M. Lu, J. R. Grover, M. Farrell, H. T. Nguyen, C. Zhao, S. Anang, M. Zhao, M. Mohammadi, M. C. Blanchard, C. Abrams, N. Madani, W. Mothes, J. C. Kappes, A. B. Smith, III, and J. Sodroski. Long-Acting BMS-378806 Analogues Stabilize the State-1 Confirmation of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins. J. Virol. 2020, 94(10), e00148-20. |
| 758. | M. C. Grenier, S. Ding, D. Vézina, J. Chapleau, W. Tolbert, M. Pazgier, A. Finzi, and A. B. Smith, III. Optimization of Small Molecules that Sensitize HIV-1 Infected Cells to Antibody Dependent Cellular Cytotoxicity. Med. Chem. Lett. 2020, 11, 371-378. |
| 756. | J. Chen, J. Park, S. M. Kirk, H-C. Chen, X. Li, D. J. Lippincott, B. Melillo, and A. B. Smith, III. Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-Trifluoroacetate Salt. Org. Process Res. Dev. 2019, 23, 2464-2469. |
| 755. | D. Deng, M. D. Nguyen, Y. Zou, K. N. Houk, A. B. Smith, III. Generation of Dithianyl and Dioxolanyl Radicals Using Photoredox Catalysis: Application in the Total Synthesis of the Danshenspiroketallactones via Radical Relay Chemistry. Org. Lett. 2019, 21,1708-1712. |
| 754. | A. Gaffney, A. Nangarlia, S. Gossert, A. A, Rashad, M. A. Hossain, C. F. Abrams, A. B. Smith, III, and I. Chaiken. Irreversible HIV-1 Inactivation Employing a Small-Molecule Dual-Action Virolytic Entry Inhibitor Strategy. ChemRxiv. 2019. |
| 753. | S. Ding, M. C. Grenier, W. D. Tolbert, D. Vézina, R. Sherburn, J. Richard, J. Prévost, J. Chapleau, G. Gendron-Lepage, H. Medjahed, C. Abrahms, J. Sodroski, M. Pazgier, A. B. Smith, III, and A. Finzi. A New Family of Small Molecule CD4-Mimetic Compounds Contact the Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates ADCC. J. Virol. 2019, 93, e01325-19. |
| 751. | C. Zhao, A. M. Princiotto, H. T. Nguyen, S. Zou, M. L. Zhao, S. Zhang, A. Herschhorn, M. Farrell, K. Pahil, B. Melillo, S. V. Sambasivarao, C. Abrams, A. B. Smith, III, N. Madani, and J. Sodroski. Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer. J. Virol. 2019, 93 (21), e01197-19. |
| 749. | M. Lu, X. Ma, L. R. Castillo-Menendez, J. Gorman, N. Alsahafi, U. Ermel, D. S. Terry, M. Chambers, D. Peng, B. Zhang, T. Zhou, N. Reichard, K. Wang, J. R. Grover, B. P. Carman, M. R. Gardner, I. Nikić-Spiegal, A. Sugawara, J. Arthos, E. A. Lemke, A. B. Smith III, M. Farzan, C. Abrams, J. B. Munro, A. B. McDermott, A. Finzi, P. D. Kwong, S. C. Blanchard, J. G. Sodroski, and W. Mothes. Associating HIV-1 Env Trimer Structured with Conformational States Defined by smFRET. Nature. 2019, 568, 415-419. |
| 748. | N. Alsahafi, N. Bakouche, M. Kazemi, J. Richard, S. Ding, S. Bhattacharyya, D. Das, S. P. Anand, J. Prévost, W. D. Tolbert, H. Lu, H. Medjahed, G. Gendron-Lepage, G. G. O. Delgado, S. Kirk, B. Melillo, W. Mothes, J. Sodroski, A. B. Smith, III, D. E. Kaufmann, X. Wu, M. Pazgier, I. Rouiller, A. Finzi, and J. B. Munro. An Asymmetric Opening of HIV-1 Env is Required for Anti-Cluster A Antibody Binding. Cell Host Microbe. 2019, 25, 578-587. |
| 747. | S. P. Anand, J. Prévost, S. Baril, J. Richard, H. Medjahed, J-P. Chapleau, W. D. Tolbert, S. Kirk, A. B. Smith, III, B. D. Wines, S. J. Kent, M. Hogarth, M. S. Parsons, M. Pazgier, A. Finzi. Two Families of Env Antibodies Efficiently Engage Fc-gamma Receptors and Eliminate HIV-1-Infected Cells. J. of Virol. 2019, 93 (3), pii:e01823-18. |
| 741. | N. Alsahafi, S. P. Anand, L. Castillo-Menendez, M. M. Verly, H. Medjahed, J. Prévost, A. Herschhorn, A. Schön, B. Melillo, E. Freire, A. B. Smith, III, J. Sodroski, A. Finzi. SOSIP Changes Affect Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformation and CD4 Engagement. J. Viro. 2018. |
| 738. | 738. F. Moraca, D. Rinaldo, A. B. Smith, III, and C. F. Abrams. Specific Noncovalent Interactions Determine Optimal Structure of a Buried Ligand Moiety: QM/MM and Pure QM Modeling of Complexes of the Small-Molecule CD4 Mimetics and HIV-1 gp120. Chem. Med. Chem., 2018, 13, 627-633. |
| 736. | A. M. Princiotto, V. D. Vrbanac, B. Melillo, J. Park, A. M. Tager, A. B. Smith, III, J. Sodroski and N. Madani. A Small-Molecule CD4 Mimetic Compound Protects BLT-mice From Human Immunodeficiency Virus Infection. J. Inf. Disease. 2018, 218(3), 471-475. |
| 732. | B. Parajuli, K. Acharya, H. C. Bach, B. Parajuli, A. B. Smith, III, C. F. Abrams and I. Chaiken. Restricted HIV-1 Env Glycan Engagement by Lectin-Reengineered DAVEI Protein Chimera is Sufficient for Lytic Inactivation of the Virus. Biochem. J. 2018, 5, 931-957. |
| 720. | A. Herschhorn, C. Gu, F. Moraca, X. Ma, M. Farrell, A. B. Smith, III, M. Pancera, P. Kwong, A. Schon, E. Freire, C. Abrams, S. C. Blanchard, W. Mothes and J. G. Sodroski. The 20-21 of gp120 is a Regulatory Switch for HIV-1 Env Conformational Transitions. Nat. Commun. 2017. (doi:10.1038/S41467-017-01119w). |
| 718. | J. Richard, J. Prévost, B. Von Bredow, S. Ding, M. Coutu, N. Brassard, B. Melillo, F. Bibollet-Ruche, B. H. Hahn, D. E. Kaufmann, A. B. Smith, III, J. Sodroski, D. Sauter, F. Kirchhoff, K. Gee, S. J. Neil, D. T. Evans and A. Finzi. BST-2 Expression Modulates Small CD4 Mimetics Sensitization of HIV-1-infected Cells to ADCC. J. Virol. 2017, 91, e00219-17. |
| 717. | J. Johnson, Y. Zhai, N. Espy, H. Salimi, N. Espy, N. Eichelberger, O. DeLeon, Y. O’Malley, J. Courter, A. B. Smith, III, N. Madani, J. Sodroski and H. Haim. Induction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States. J. Virol. 2017, 91, e00174-17. |
| 713. | B. Pacheco, N. Alsahafi, O. Debbeche, S. Ding, J.-P. Chapleau, A. Herschhorn, N. Madani, A. Princiotto, C. Gu, X. Zeng, Y. Mao, A. B. Smith, III, J. Sodroski and A. Finzi. Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-directed Inhibitors. J. Virol. 2017, 92, e-2219-16. |
| 711. | N. Madani, A. M. Princiotto, C. Zhao, F. Jahanbakhshsefidi, M. Mertens, A. Herschhorn, B. Melillo, A. B. Smith, III and J. Sodroski. Activation and Inactivation of the Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds. J. Virol. 2017, 91, e01880-16. |
| 706. | S. Ding, M. M. Verly, A. Princiotto, N. Brassard, B. Melillo, A. M. Moody, T. Bradley, D. Easterhoff, B. H. Hahn, D. E. Kaufmann, N. Madani, A. B. Smith, III, B. Haynes, J. Sodroski and A. Finzi. Small-Molecule CD4 Mimetics Sensitize HIV-1-infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates. Aids Res. Hum. Retroviruses 2016, 33, 428-431. |
| 705. | T. Bradley, A. Trama, N. Tumba, E. Gray, X. Lu, N. Madani, F. Jahanbakhsh, A. Eaton, S.-M. Xia, R. Parks, K. E. Lloyd, L. L. Sutherland, R. M. Scearce, C. M. Bowman, S. Barnett, S. S. Abdool-Karim, S. Boyd, B. Melillo, A. B. Smith, III, J. Sodroski, T. B. Kepler, S. M. Alam, F. Gao, M. Bonsignori, H.-X. Liao, M. A. Moody, D. Montefiori, S. Santra, L. Morris and B. F. Haynes. Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. E Bio Medicine 2016, 12, 196-207. |
| 703. | J. Richard, B. Pacheco, N. Gohain, M. Veillette, S. Ding, N. Alsahafi, W. D. Tolbert, J. Prévost, J.-P. Chapleau, M. Coutu, M. Jia, N. Brassard, J. Park, J. R. Courter, B. Melillo, L. Martin, C. Tremblay, B. H. Hahn, D. E. Kaufmann, X. Wu, A. B. Smith, III, J. Sodroski, M. Pazgier and A. Finzi. Co-Receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-Cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins. E Bio Medicine 2016, 12, 208-218. |
| 701. | F. Moraca, K. Acharya, B. Melillo, A. B. Smith, III, I. Chaiken and C. F. Abrams. Computational Evaluation of HIV-1 gp120 Conformations of Soluble Trimeric gp140 Structures as Targets for De Novo Docking of First and Second Generation of Small-Molecule CD4 Mimetics. J. Chem. Inf. Model. 2016, 56, 2069-2079. |
| 700. | A. Hershhorn, X. Ma, C. Gu, D. Ventura, L. Castillo-Menendez, B. Melillo, D. S. Terry, A. B. Smith, III, S. Blanchard, J. B. Munro, W. Mothes, A. Finzi and J. Sodroski. Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. mBio. 2016, 7, 01598-16. |
| 697. | N. Madani, A. M. Princiotto, D. Easterhoff, T. Bradley, K. Luo, W. B. Williams, H.-X. Liao, M. A. Moody, G. E. Phad, N. V. Bernat, B. Melillo, A. B. Smith, III, G. B. K. Hedestam, B. Haynes and J. Sodroski. Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J. Virol. 2016, 90, 5031-5046. |
| 694. | J. Richard, M. Veillette, S. Ding, D. Zoubchenok, N. Alsahafi, M. Coutu, N. Brassard, J. Park, J. R. Courter, B. Melillo, A. B. Smith, III, G. M. Shaw, B. H. Hahn, J. Sodroski, D. E. Kaufmann and A. Finzi. Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity. E. Bio Medicine 2016, 3, 122-134. |
| 691. | B. Melillo, S. Liang, J. Park, A. Schon, J. R. Courter, J. M. LaLonde, D. J. Wendler, A. M. Princiotto, M. S. Seaman, E. Freire, J. Sodroski, N. Madani, W. A. Hendrickson and A. B. Smith, III. Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. ACS Med Chem Lett 2016, 26, 330-334. |
| 686. | W. S. Lee, J. Richard, M. Lichtfuss, A. B. Smith, III, J. Park, J. R. Courter, B. N. Melillo, J. G. Sodroski, D. E. Kaufmann, A. Finzi, M. S. Parsons and S. J. Kent. Antibody-Dependent Cellular Cytotoxicity Against Reactivated HIV-1-Infected Cells. J. Virol. 2016. 2016, 90, 2021-2030. |
| 684. | B. Melillo, M. Z. Chen, R. Forestieri and A. B. Smith, III. An Effective Bifunctional Aldehyde Linchpin for Type II Anion Relay Chemistry: Development and Application to the Synthesis of a C16-C29 Fragment of Rhizopodin. Org. Lett. 2015, 17, 6242-6245. |
| 673. | J. Richard, M. Veillette, N. Brassard, S. S. Iyer, M. Roger, L. Martin, M. Pazgier, J.-P. Routy, A. B. Smith, III, J. Park, D. M. Jones, J. R. Courter, B. N. Melillo, D. E. Kaufmann, B. H. Hahn, S. Permar, B. F. Haynes, N. Madani, J. Sodroski and A. Finzi. CD4 Mimetics Sensitize HIV-1-Infected Cells to ADCC. Proc. Natl. Acad. Sci. USA 2015, 112, E2687-E2694. PMC4443331. |
| 665. | J. B. Munro, J. Gorman, X. Ma, J. Arthos, D. R. Burton, W. C. Koff, J. R. Courter, A. B. Smith, III, P. D. Kwong, S. C Blanchard and W. Mothes. Conformational Dynamics of Single HIV-1 Env Trimers on the Surface of Native Virions. Science 2014, 346, 759-763. PMC4304640. |
| 661. | J. R. Courter, N. Madani, J. Sodroski, A. Schon, E. Freire, P. D. Kwong, W. A. Hendrickson, I. M. Chaiken, J. M. LaLonde and A. B. Smith, III. Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist. Acc. Chem. Res. 2014, 47, 1228-1237. PMC3993944. |
| 659. | N. Madani, A. M. Princiotto, A. Schön, J. LaLonde, Y. Feng, E. Freire, J. Parks, J. Courter, D. Jones, J. Robinson, H.-X. Liao, M. A. Moody, S. Permar, B. Haynes, A. B. Smith, III, R. Wyatt and J. Sodroski. CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus (HIV-1) to Vaccine-Elicited Antibodies. J. Virol. 2014, 88, 6542-6555. |
| 656. | Y. D. Kwon, J. M. LaLonde, Y. Yang, M. A. Elban, A. Sugawara, J. R. Courter, D. M. Jones, A. B. Smith, III, A. K. Debnath and P.D. Kwong. Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues that Target the CD4 Binding Site. PLoS One. 2014, 9, e85940. PMC3904841. |
| 644. | T. Fricke, A. Brandariz-Nunez, X. Wang, A. B. Smith, III and F. Diaz-Griffero. Human Cytosolic Extracts Stabilize the HIV-1 Core. J. Virol. 2013, 87, 10587-10597. PMC3807412. |
| 635. | J. M. LaLonde, M. Le-Khac, D. M. Jones, J. R. Courter, J. Park, A. Schon, A. M. Princiotto, X. Wu, J. R. Mascola, E. Freire, J. Sodroski, N. Madani, W. A. Hendrickson and A. B. Smith, III. Structure-Based Optimization of a Small Molecule HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med. Chem. Lett. 2013, 4, 338-343. NIHMSID445081. |
| 623. | S. Kortagere, N. Madani, M. K. Mankowski, A. Schön, I. Zentner, G. Swaminathan, A. Princiotto, K. Anthony, A. Oza, L.-J. Sierra, S. R. Passic, X. Wang, D. M. Jones, E. Stavale, F. C. Krebs, J. Martínez-García, E. Freire, R. G. Ptak, J. Sodroski, S. Cocklin and A. B. Smith, III. Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid. J. Virol. 2012, 86, 8472-8481. |
| 620. | J. M. LaLonde, Y. D. Kwon, D. M. Jones, A. W. Sun, J. R. Courter, T. Soeta, T. Kobayashi, A. M. Princiotto, X. Wu, J. Mascola, A. Schon, E. Freire, P. D. Kwong, J. Sodroski, N. Madani and A. B. Smith, III. Structure-Based Design, Synthesis and Characterization of Dual Hot Spot Small-Molecule HIV-1 Entry Inhibitors. J. Med. Chem. 2012, 55, 4382-4396. PMC3376652. |
| 613. | A. Herschhorn, A. Finzi, D. Jones, J. R. Courter, A. Sugawara, A. B. Smith, III and J. Sodroski. An Inducible Cell-cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors. PLoS 2011, 6, e26731. |
| 606. | H. Haim, B. Strack, A. Kassa, N. Madani, L. Wang. J. Courter, A. Princiotto, K. McGee, B. Pacheco, M. S. Seeman, A. B. Smith, III and J. Sodroski. Contribution of Intrinsic Reactivity of the HIV-1 Envelope Glycoprotein to CD4-Independent Infection and Global Inhibitor Sensitivity. PLoS Pathogen 2011, 7, e1002101. PMC3121797. |
| 603. | S. A. Kuriakose, I. J. Zentner, A. Schön, K. McFadden, M. Umashankara, S. Rajagopal, M. Contarino, C. Duffy, J. Courter, D. Jones, M.-Y. Zhang, J. M. Gershoni, S. Cocklin, D. S. Dimitrov, A. B. Smith, III, E. Freire, I. M. Chaiken. Conformational and Structural Features of HIV-1 gp120 Underlying its Dual Antagonism by the Cross-Reactive Neutralizing Antibody, m18. Biochemistry 2011, 50, 2756-2768. PMC3088361. |
| 596. | A. Schön, N. Madani, A. B. Smith, III, J. M. LaLonde and E. Freire. Some Binding-RelatedDrug Properties are Dependent on Thermodynamic Signature. Chem. Biol. Drug Des. 2011, 77, 161-165. PMC3079564. |
| 595. | J. M. LaLonde, M. Elban, J. Courter, A. Sugawara, T. Soeta, N. Madani, A. M. Princiotto, Y. D. Kwon, P. D. Kwong, A. Schön, E. Freire, J. Sodroski and A. B. Smith, III. Design, Synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorg. Med. Chem. 2011, 19, 91-101. PMC3049263. |
| 579. | H.-S. Lee, M. Contarino, M. Umashankara, A. Schoen, E. Freire, A. B. Smith, III, I. M. Chaiken, M. Irwin and L. S. Penn. Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120. Anal. Bioanal. Chem. 2010, 396, 1143-1152. PMC2903444. |
| 573. | A. Kassa, N. Madani, A. Schön, H. Haim, A. Finzi, S. Xiang, L. Wang, A. Princiotto, M. Pancera, J. Courter, E. Freire, P.D. Kwong, A.B. Smith, III and J. Sodroski. Transitions to and from the CD4-bound Conformation are Modulated by a Single-Residue Change in the HIV-1 gp120 Inner Domain. J. Virol. 2009, 83, 8364-8378. PMC2738180. |
| 555. | H. Haim, Z. Si, N. Madani, L. Wang, J.R. Courter, A. Princiotto, A. Kassa, M. DeGrace, K. McGee-Estrada, M. Mefford, D. Gabuzda, A.B. Smith, III and J. Sodroski. Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathogens. USA. 2009, 5(4): e1000360. PMC2655723. |
| 542. | H. Gopi, M. Umashankara, V. Pirrone, J. LaLonde, N. Madani, F. Tuzer, S. Baxter, I. Zentner, S. Cocklin, N. Jawanda, S. R. Miller, A. Schön, J. C. Kelin, E. Freire, F. C. Krebs, A. B. Smith, III, J. Sodroski and I. Chaiken. Structural Determinants for Affinity Enhancement of a Dual Antagonist Peptide Entry Inhibitor of Human Immunodeficiency Virus Type-1. J. Med. Chem. 2008, 51, 2638-2647. PMC2921370. |
| 530. | H. Xie, D. Ng, S. Savinov, B. Dey, P. D. Kwong, R. Wyatt, A. B. Smith, III, and W. A. Hendrickson. Structure-activity Relationship in the Binding of Chemically Derivatized CD4 to HIV gp120. J. Med. Chem. 2007, 50, 4898-4908. |
| 515. | A. Schön, J. C. Klein, N. Madani, D. Ng, A. B. Smith, III, J. Sodroski, and E. Freire. Binding Thermodynamics of a Small Molecular Weight CD4 Mimetic to NIV-1 gp120. Biochemistry. 2006, 45, 10973-10980. |
| 460. | Z. Si, N. Madani, J. M. Cox, J. J. Chruma, J. C. Klein, A. Schoen, N. Phan, L. Wang, A. C. Biorn, S. Cocklin, I. Chaiken, E. Freire, A. B. Smith, III, and J. G. Sodroski. Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proc. Natl. Acad. Sci. USA. 2004,101, 5036-5041. |
| 442. | P. V. Murphy, J. L. O’Brien, L. J. Gorey-Feret, and A. B. Smith, Ill. Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds. Tetrahedron 2003, 59, 2259-2271. |
| Bioorganic Chemistry / Medicinal Chemistry | |
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| 598. | K. R. Brunden, Y. Yao, J. Potuzak, N. I. Ferrer, C. Ballatore, M. James, A.-M. L. Hogan, J. Q. Trojanowski, A. B. Smith, III and V. M.-Y. Lee. The Characterization of Microtubule-Stabilizing Drugs as Possible Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies. Pharmacological Research. 2011, 63, 341-351. PMC3042036. |
| 594. | C. P. des Gachons, K. Uchida, B. Bryant, A. Shima, J. B. Sperry, L. Dankulich-Nagrudny, M. Tominaga, A. B. Smith, III, G. K. Beauchamp and P. A. S. Breslin. Unusual pungency from extra-virgin olive oil is due to restricted spatial expression of oleocanthal’s receptor. J. Neurosci. 2011, 31, 999-1009. PMC3073417. |
| 593. | C. Ballatore, K. R. Brunden, J. Q. Trojanowski, V. M-Y. Lee, A. B. Smith, III and D. Huryn. Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies. Curr. Top. Med. Chem. 2011, 11, 317-330. PMC3069499 |
| 590. | K. R. Brunden, B. Zhang, J. Carroll, Y. Yao, J. S. Potuzak, A.-M. Hogan, M. Iba, M. J. James, S. X. Xie, C. Ballatore, A. B. Smith, III, V. M.-Y. Lee, and J. Q. Trojanowski. Epothilone D Improves Microtubule Density, Axonal Integrity and Cognition in a Transgenic Mouse Model of Tauopathy. J. Neurosci. 2010, 30, 13861-13866. PMC2958430. |
| 585. | C. Ballatore, K. R. Brunden, F. Piscitelli, M. James, A. Crowe, M. Yao, J. Q. Trojanowski, V. M.-Y. Lee and A. B. Smith, III. Discovery of a Brain-Penetrant and Orally Bioavailable Aminothienopyridazine Inhibitor of Tau Aggregation. J. Med. Chem. 2010, 53, 3739-3747. PMC2872922. |
| 566. | R. F. Hirschmann, K. C. Nicolaou, A. R. Angeles, J. S. Chen, and A. B. Smith, III. The β-D-Glucose Scaffold as a β-Turn Mimetic. Acc. Chem. Res. 2009, 42, 1511-1520. |
| 557. | W. Li, J. Sperry, A. Crowe, I. V. J. Murphy, P. H. Axelsen, A. B. Smith, III, J. Q. Trojanowski, V. M. Y. Lee. Inhibition of Tau Fibrillization by Oleocanthal via Reaction with the Amino Groups of Tau. J. Neurochem. 2009, 110, 1339-1351. PMC2758489. |
| 541. | M. P. Beavers, M. C. Myers, P. P. Shah, J. E. Purvis, S. L. Diamond, B. S. Cooperman, D. M. Huryn, and A. B. Smith, III. Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain. J. Chem. Inf. Model 2008, 48, 1464-1472. PMC2923042. |
| 516. | S. Xian, C. Kenesky, P. V Rucker, A. B. Smith, III, G. A. Orr, and S. B. Horwitz. A Photoaffinity Analogue of Discodermolide Specifically Labels a Peptide in β-Tubulin. Biochemistry. 2006, 45, 11762-11775. |
| 510. | S. Foister, L. L. Taylor, J.-J. Feng, W.-L. Chen, A. Lin, F.-C. Cheng, A. B. Smith, III, and R. F. Hirschmann. Design and Synthesis of a Potent Cystine-Free Cyclic Hexapeptide Agonist at the Human Urotensin Receptor. Org. Lett. 2006, 8, 1799-1802. |
| 495. | A. B. Smith, III, Q. Han, P. A. S. Breslin, and G. K. Beauchamp. Synthesis and Assignment of Absolute Conformation of (–)-Oleocanthal: A Potent, Naturally Occurring Non-Steroidal Anti-Inflammatory and Anti-Oxidant Agent Derived from Extra Virgin Olive Oils. Org. Lett. 2005, 7, 5075-5078. |
| 490. | G. Beauchamp, R. Keast, D. Morel, J. Lin, J. Pika, Q. Han, C.-H. Lee, A. B. Smith, III, and P. Breslin. Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature 2005, 437, 45-46. |
| 484. | A. B. Smith, III, R. J. Fox, and J. A. Vanecko. (+)-Sorangicin A Synthetic Studies. Construction of the C(1-15) and C(16-29) Subtargets. Org. Lett. 2005, 7, 3099-3102. |
| 444. | A. B. Smith, III, L.-D. Cantin, A. Pasternak, L. Guise-Zawacki, W. Yao, A. Charnleyl J. Barbosa, P. A. Sprengeler, R. Hirschmann, S. Munshi, D. B. Olsen, W. A. Schleif and L. C. Kuo. Design, Synthesis and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors. J. Med. Chem. 2003, 46, 1831-1844. |
| 419. | Martello, L. A.; LaMarche, M. J.; He, L.; Beauchamp, T. J.; Smith, A. B.; Horwitz, S. B. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & Biology (2001), 8(9), 843-855. |
| 402. | Smith, Amos B., III; Wang, Wenyong; Sprengeler, Paul A.; Hirschmann, Ralph. Design, Synthesis, and Solution Structure of a Pyrrolinone-Based b-Turn Peptidomimetic. Journal of the American Chemical Society (2000), 122(44), 11037-11038. |
| 379. | Smith, Amos B., III; Benowitz, Andrew B.; Sprengeler, Paul A.; Barbosa, Joseph; Guzman, Mark C.; Hirschmann, Ralph; Schweiger, Edwin J.; Bolin, David R.; Nagy, Zoltan; Campbell, Robert M.; Cox, Donald C.; Olson, Gary L. Design and Synthesis of a Competent Pyrrolinone-Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1. Journal of the American Chemical Society (1999), 121(40), 9286-9298. |
| 341. | Smith, Amos B., III; Hirschmann, Ralph; Pasternak, Alexander; Yao, Wenquing; Sprengeler, Paul A.; Holloway, M. Katharine; Kuo, Lawrence C.; Chen, Zhongguo; Darke, Paul L.; Schleif, William A. An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex. Journal of Medicinal Chemistry (1997), 40(16), 2440-2444. |
| 105. | Smith, Amos B., III; Belcher, Anne M.; Epple, Gisela; Jurs, Peter C.; Lavine, Barry. Computerized pattern recognition: a new technique for the analysis of chemical communication. Science (Washington, DC, United States) (1985), 228 (4696), 175-7. |
| Biophysics / Materials Science | |
|---|---|
| 584. | M. J. Tucker, J. R. Courter, J. Chen, A. B. Smith, III and R. M. Hochstrasser. Tetrazine phototriggers: Probes for protein dynamics. Angew. Chem. Int. Ed. 2010, 49, 3612-3616. PMC2903731. |
| 558. | S. Bagchi, A. K. Charnley, A. B. Smith, III and R. M. Hochstrasser. Equilibrium exchange processes of the aqueous Tryptophan dipeptide. J. Phys. Chem. B. 2009, 113, 8412-8417. PMC2929808. |
| 469. | J. Tang, E. Mei, J. Kaplan, C. Green, W. F. DeGrado, A. B. Smith III and R. M. Hochstrasser. 1. Probing Structural Dynamics of Individual Calmodulin: Peptide Complexes in Hydrogel by Single Molecule Confocal Microscopy. J. Phys. Chem. B. 2004, 108, 15910-15918. |
| 466. | C. Fang, J. Wang, Y. S. Kim, A. K. Charnley, W. Barber-Armstrong, A. B. Smith, III, S. M. Decatur, and R. M. Hochstrasser. Two-Dimensional Infrared Spectroscopy of lsotopomers of an Alanine-rich α Helix. J. Phys. Chem. B, 2004, 108, 10415-10427. |
| 454. | C. Fang, J. Wang, A. K. Charnley, W. Barber-Armstrong, A. B. Smith, III, S. M. Decatur, and R. M. Hochstrasser. Two-dimensional infrared measurements of the coupling of amide modes of an α-helix. Chem. Phys. Lett. 2003, 382, 586-592. |
| 361. | Khong, Anthony; Jimenez-Vazquez, Hugo A.; Saunders, Martin; Cross, R. James; Laskin, Julia; Peres, Tikva; Lifshitz, Chava; Strongin, Rob; Smith, Amos B., III. An NMR Study of He2 Inside C70. Journal of the American Chemical Society (1998), 120(25), 6380-6383. |
| 301. | Smith, Amos B., III; Strongin, Robert M.; Brard, Laurent; Furst, George T.; Romanow, William J.; Owens, Kevin G.; Goldschmidt, Robert J.; King, Richard C. Synthesis of Prototypical Fullerene Cyclopropanes and Annulenes. Isomer Differentiation via NMR and UV Spectroscopy. Journal of the American Chemical Society (1995), 117(20), 5492-502. |
| 213. | J. E. Fischer, P. A. Heiney, and A. B. Smith, III, “Solid State Chemistry of Fullerene-Based Materials,” Acc. Chem. Res., 25, 112-118 (1992). |
| 155. | M. Lee, J. N. Haseltine, A. B. Smith, III, and R. M. Hochstrasser. lsomerization Processes of Electronically Excited Stilbene and Diphenylbutadiene in Liquids: Are They One-Dimensional? J. Am. Chem. Soc. 1989, 111, 5044-5051. |
| 145. | V. L. Windisch, A. B. Smith, III, and R. M. Hochstrasser. Unimolecular Photodissociation of s-Tetrazine and Derivatives. J. Phys. Chem. 1988, 92, 5366-5370. |
| 041. | B. Dellinger, M. A. Paczkowski, R. M. Hochstrasser, and A. B. Smith, III. Observation of Transient Intermediates in the Photochemical Decomposition of Substituted s-Tetrazines. J. Am. Chem. Soc. 1978, 100, 3242-3243. |
| 031. | B. Dellinger, D. S. King, R. M. Hochstrasser, and A. B. Smith, III. Laser Induced Isotope Enrichment in a Rare Gas Matrix. J. Am. Chem. Soc. 1977, 99, 3197-3198. |