Spongistatin

Referenced Publications:
Smith, Amos B., III; Zhuang, Linghang; Brook, Christopher S.; Boldi, Armen M.; Mcbriar, Mark D.; Moser, William H.; Murase, Noriaki; Nakayama, Kiyoshi; Verhoest, Patrick R.; Lin, Qiyan. Spongistatin synthetic studies. 1. Construction of a C(29-48) subtarg
Smith, Amos B., III; Zhuang, Linghang; Brook, Christopher S.; Lin, Qiyan; Moser, William H.; Trout, Robert E. Lee; Boldi, Armen M. Spongistatin synthetic studies. 2. Assembly of the C(18-28) spiroketal. Tetrahedron Letters (1997), 38(50), 8671-8674.
Smith, Amos B., III; Lin, Qiyan; Nakayama, Kiyoshi; Boldi, Armen M.; Brook, Christopher S.; Mcbriar, Mark D.; Moser, William H.; Sobukawa, Masao; Zhuang, Linghang. Spongistatin synthetic studies. 3. Construction of the C(1-17) spiroketal. Tetrahedron Lett
Smith, Amos B.; Lin, Qiyan. Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains. Bioorganic & Medicinal Chemistry Letters (1998), 8(6), 567-568.
A. B. Smith, III, V. A. Doughty, Q. Lin, L.-H. Zhuang, M. D. McBriar, A. M. Boldi, W. H. Moser, N. Murase, K. Nakayama, and M. Sobukawa. The Spongistatins: Architecturally Complex Natural Products. Part One: A Formal Synthesis of (+)-Spongistatin 1
Smith, Amos B., III; Lin, Qiyan; Doughty, Victoria A.; Zhuang, Linghang; McBriar, Mark D.; Kerns, Jeffrey K.; Brook, Christopher S.; Murase, Noriaki; Nakayama, Kiyoshi. The spongistatins: architecturally complex natural products. Part two. Synthesis of th
A. B. Smith, III, V. A. Doughty, C. Sfouggatakis, C. S. Bennett, J. Koyanagi and M. Takeuchi. Spongistatin Synthetic Studies. An Efficient, Second-Generation Construction of an Advanced ABCD Intermediate. Org. Lett. 2002, 4, 783-786.
A. B. Smith, III, R. M. Corbett, G. R. Pettit, J.-C. Chapuis, J. M. Schmidt, E. Hamell and M. Katherine Jung. Synthesis and Biological Evaluation of a Spongistatin AB-Spiroketal Analog. Bioorg. Med. Chem. Lett. 2002, 12, 2039-2042.
A. B. Smith, III, W. Zhu, S. Shirakami, C. Sfouggatakis, V. A. Doughty, C. S. Bennett, and Y. Sakamoto. Total Synthesis of (+)-Spongistatin 1. An Effective, Second-Generation Construction of an Advanced EF Wittig Salt, Fragment Union, and Final Elab
A. B. Smith, III, and C. M. Adams. Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products. Acc. of Chem. Res. 2004, 37, 365-377.
A. B. Smith, III, C. Sfouggatakis, D. B. Gotcehv, S. Shirakami, D. Bauer, W. Zhu, and V. A. Doughty. Spongistatin Synthetic Studies. Evolution of a Scalable Synthesis of the EF Fragment of (+) Spongistatin 1 Exploiting the Petasis-Ferrier Union/Rea
A. B. Smith, III, R. J. Fox, and T. M. Razler. Evolution of the Petasis-Ferrier Union/Rearrangement Tactic: Construction of Architecturally Complex Natural Products Possessing the Ubiquitous cis-2,6-Substituted Tetrahydropyran Structural Element.
A. B. Smith, III, T. Tomioka, C. A. Risatti, J. B. Sperry, and C. Sfouggatakis. Gram-Scale Synthesis of (+)-Spongistatin 1. An Improved, Scalable Synthesis of the F-Ring Subunit, Fragment Union, and Final Elaboration. Org. Lett. 2008, 10, 4359-436
A. B. Smith, III, C. Sfouggatakis, C. A. Risatti, J. B. Sperry, W. Zhu, V. A. Doughty, T. Tomioka, D. B. Gotchev, C. S. Bennett, S. Sakamoto, O. Atasoylu, S. Shirakami, D. Bauer, M. Takeuchi, J. Koyanagi and Y. Sakamoto. Spongipyran Synthetic Studie
O. Atasoylu, G. Furst, C. Risatti and A. B. Smith, III. The Solution Structure of (+)-Spongistatin 1 in DMSO. Org. Lett. 2010, 12, 1788-1791. PMC2856070.
A. B. Smith, III, C. A. Risatti, O. Atasoylu, C. S. Bennett, K. TenDyke and Q. Xu. Design, Synthesis and Biological Evaluation of EF- and ABEF- Analogs of (+)-Spongistatin 1. Org. Lett. 2010, 12, 1792-1795. PMC2853872.