The Olive Oil Story – Monell Chemical Senses Center Collaboration

The Olive Oil Story – Monell Chemical Senses Center Collaboration

Referenced Publications:

G. Beauchamp, R. Keast, D. Morel, J. Lin, J. Pika, Q. Han, C.-H. Lee, A. B. Smith, III, and P. Breslin. Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature 2005, 437, 45-46.

A. B. Smith, III, M. Xian, and F. Liu. Design, Synthesis and Biological Evaluation of C13-C14 Cyclopropane Analogs of Discodermolide. Org. Lett. 2005, 7, 4613-4616.

A. B. Smith, III, J. B. Sperry and Q. Han. Synthesis of (−)-Oleocanthal, a Natural NSAID Found in Extra Virgin Olive Oil, (−)-Deacetoxy-oleuropein Aglycone and Related Analogies. J. Org. Chem. 2007, 72, 6891-6900.

W. Li, J. Sperry, A. Crowe, I. V. J. Murphy, P. H. Axelsen, A. B. Smith, III, J. Q. Trojanowski, V. M. Y. Lee. Inhibition of Tau Fibrillization by Oleocanthal via Reaction with the Amino Groups of Tau. J. Neurochem. 2009, 110, 1339-1351. PMC275848

J. Pitt, W. Roth, P. Lacor, A. B. Smith, III, M. Blankenship, P. Velasco, F. DeFelice, P. Breslin and W. L. Klein. Alzheimer’s-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxic

J. B. Sperry; A. B. Smith, III “Synthesis of Diverse Phenolic Compounds Isolated From Olive Oils”, in Olives and Olive Oil in Health and Disease Prevention; V.R. Preedy; R.R. Watson, eds; Academic Press, London, 2010, pp. 1439-1464.

A. Iacono, R. Gómez, J. Sperry, J. Conde, G. Bianco, R. Meli, A. B. Smith, III and O. Gualillo. Effect of oleocanthal and its derivatives on inflammatory response induced by LPS in chondrocyte cell line. Arthritis Rheum. 2010, 62, 1675-1682. PMID202

C. P. des Gachons, K. Uchida, B. Bryant, A. Shima, J. B. Sperry, L. Dankulich-Nagrudny, M. Tominaga, A. B. Smith, III, G. K. Beauchamp and P. A. S. Breslin. Unusual pungency from extra-virgin olive oil is due to restricted spatial expression of oleo