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LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate

Published in Nature Communications; see news writeup:


Floral organ appear on reprogrammed Arabidopsis roots explants

The LEAFY transcription factor reprograms root explants to form flowers by acting as a pioneer transcription factor. Work by grad students Run Jin and  Sammy Klasfeld together with postdoc Yang Zhu

molecular visualization of LFY which highlights DNA binding domain shallow contact of DNA

The DNA binding domain of LEAFY makes shallow contacts allowing simultaneous access of the transcription factor and the histone octamer


Figure 1B of Jin et al 2021

LEAFY binds nucleosomal DNA in vitro and in vivo