Publications

148. L. Mazaleuskaya, S. Lee, H. Meng, J. Winkler, G. FitzGerald,”Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain,” Bioorganic & Medicinal Chemistry Letters 2021, 50, 128313.

147. Y. Wang, V. Jain, A. Versace, M. Crissey, R. Amaravadi, J. Winkler, “Anticancer properties of bisaminoquinolines with modified linkers,” Bioorganic & Medicinal Chemistry Letters 2021, 49, 128272.

146. K. Doytchinova, J. Winkler, “Synthesis of the Core Ring System of the Antiosteoporotic Citrofulvicin,” Org. Lett. 2021, 23 (12), 4575-4578.

145. T. Higgins, S. Lee, J. Winkler, “Synthesis of and Metal Complexation with a Chiral Cyclam,” J. Org. Chem. 2021, 86 (7), 5417-5422.

144. H. Jeon, J. Winkler, “Synthesis of Cyclohexane-Angularly-Fused Triquinanes,” Synthesis 2021, 53 (03), 475-488.

143. C. Xu, L. Wang, P. Fozouni, G. Evjen, V. Chandra, J. Jiang, C. Lu, M. Nicastri, C. Bretz, J. Winkler, R. Amaravadi, B. Garcia, P. Adams, M. Ott, W. Tong, T. Johansen, Z. Dou, S. Berger, “SIRT1 is downregulated by autophagy in senescence and ageing,” Nature Cell Biology 2020, 22 (10), 1170.

142. G. Sharma, R. Ojha, E. Noguera-Ortega, V. Rebecca, J. Attanasio, S. Liu, S. Piao, J. Lee, M. Nicastri, S. Harper, A. Ronghe, V. Jain, J. Winkler, D. Speicher, J. Mastio, P. Gimotty, X. Xu, E. Wherry, D. Gabrilovich, R. Amaravadi, “PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma,” JCI Insight 2020,  5 (17).

141. X. Zhao, K. Lorent, D. Escobar-Zarate, R. Rajagopalan, K. Loomes, K. Gillespie, C. Mesaros, M. Estrada, I. Blair, J. Winkler, N. Spinner, M. Devoto, M. Pack, “Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia,” Gastroenterology 2020, 159 (3), 1068.

140. T. Higgins, J. Winkler, “Synthesis and Applications of the C-2-Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane,” J. Org. Chem. 2020, 85 (11), 7424-7432.

139. K. Crocker, Y. Pei, E. Robertson, J. Winkler, “Synthesis of a novel bruceantin analog via intramolecular etherification,” Canadian Journal of Chemistry 2020, 98 (6), 270-272.

138. L. Cechakova, M. Ondrej, V. Pavlik, P. Jost, D. Cizkova, A. Bezrouk, J. Pejchal, R. Amaravadi, J. Winkler, A. Tichy, “A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299,” Internation Journal of Molecular Sciences 2019, 20 (23).

137. Q. Yan, P. Carroll, M. Gau, J. Winkler, M. Joullie, “A Transannular Rearrangement Reaction of a Pyrroloindoline Diketopiperazine,” Org. Lett. 2019, 21 (17), 6619-6623.

136. P. Wangtrakuldee, A. Adeniji, T. Zang, L. Duan, B. Khatri, B. Twenter, M. Estrada, T. Higgins, J. Winkler, T. Penning, “A 3-​(4-​nitronaphthen-​1-​yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics,” Journal of Steroid Biochemistry and Molecular Biology 2019, 192. (https://doi.org/10.1016/j.jsbmb.2019.01.001)

135. P. Baquero, A. Dawson, A. Mukhopadhyay, E. Kuntz, R. Mitchell, O. Olivares, A. Iannicello, M. Scott, K. Dunn, M. Nicastri, J. Winkler, A. Michie, K. Ryan, C. Halsey, E. Gottlieb, E. Keaney, L. Murphy, R. Amaravadi, T. Holyoke, G. Helgason, “Targeting quiescent leukemic stem cells using second generation autophagy inhibitors,” Leukemia, 2019, 33 (4), 981-994.

134. V. Rebecca, M. Nicastri, C. Fennelly, C. Chude, J. Barber-Rotenberg, A. Ronghe, Q. McAfee, N. McLaughlin, G. Zhang, A.Goldman, R. Ojha, S. Piao, E. NogueraOrtega, A. Martorella, G. Alicea, J. Lee, L. Schuchter, X. Xu, M. Herlyn, R.Marmorstein, P. Gimotty, D. Speicher, J. Winkler and R. Amaravadi, “PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer,” Cancer Discovery 2019, 9, 220-229.

133. S. Goldstein, C. Liu, M. Safo, A. Nakagawa, W. Zapol, J. Winkler, “Design, Synthesis and Biological Evaluation of Allosteric Effectors that Enhance CO Release from Carboxyhemoglobin,” ACS Med. Chem. Lett. 2018, 9, 714-718.

132. M. Grasso, M. Estrada, K. Berrios, J. Winkler, R. Marmorstein, N-(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF Through the Induction of Inhibited Dimers,” J. Med. Chem. 2018, 61, 5034-5046.

131. M. Estrada, X. Zhao, K. Lorent, A. Kriegermeier, S. Nagao, S. Berritt, R. Wells, M. Pack. J. Winkler, “Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia,” ACS Med. Chem. Lett, 2018, 9, 61-64.

130. E. Nakamura, J. Winkler, V. Aggarwal, “Gilbert Stork,” Ang. Chem. Int. Ed. doi:10.1002/anie.201711474

129. M. Nicastri, V. Rebecca, R. Amaravadi, J. Winkler, “Dimeric Quinacrines as Chemical Tools to Identify PPT1, a New Regulator of Autophagy,” Mol. Cell. Oncol. 2017, in press.

128. S. Piao, R. Ojha, V. Rebecca, A. Samanta, X. Ma. Q. McAfee, M. Nicastri, M.Buckley, E. Brown, J. Winkler, P. Gimotty, R. Amaravadi, “ALDH1A1 and HLTF Modulate the Activity of Lysosomal Autophagy Inhibitors,” Autophagy 2017, 1-16.

127. V. Rebecca, M. Nicastri, N. McLaughlin, C. Fennelly, Q. McAfee, A. Ronghe, M. Nofal, C. Lim, E. Witze, C. Chude, G. Zhang, G. Alicea, S. Piao, S. Murugan, R. Ojha, S. Levi, Z. Wei, J. Barber-Rotenberg, M. Murphy, G. Mills, Y. Lu, J. Rabinowitz, R. Marmorstein, Q. Liu, S. Liu, X. Xu, M. Herlyn. R. Zoncu, D. Brady, D. Speicher, J. Winkler, R. Amaravadi, “A Unified Approach to Targeting the Lysosome’s Degradative and Growth Signal Notes,” Cancer Discovery 2017, 7, 1266-1283.

126. A. Ndoye, A. Budina-Kolomets, C. Kugel, M. Webster, A. Kaur, R. Behera, V. Rebecca, L. Li, P. Brafford, Q. Liu, Y. Gopal, M. Davies, G. Milles, X. Xu, H. Wu, M. Herlyn, M. Nicastri, J. Winkler, M. Soengas, R. Amaravadi, M. Murphy, A. Weeraratna, “ATG5 Mediates a Positive Feedback Loop Between Wnt Signaling and Autophagy in Melanoma,” Cancer Res. 2017, 77, 2873-5885.

125. S. Vijayaraghavan, C. Karakas, I. Doostan, X. Chen, T. Bui, Min Yi, A. Raghavenddra, Y. Zhao, S. Bashour, N. Ibrahim, M. Karuturi, J. Wang, J. Winkler, R. Amaravadi, K. Hunt, D. Tripathy, K. Keyomarsi, “CDK4/6 and Autophagy Inhibitors Synergistically Induce Senescence in Rb Positive Cytoplasmic Cyclic E Negative Cancers,” Nature Comm. 2017, 8 15916 (doi:10.1038/ncomms15916).

124. K. Whelan, P. Chandramouleeswaran, K. Tanaka, M. Natsuizaka, M. Guha, S. Srinivasan, D. Darling, Y. Kita, S. Natsugoe, J. Winkler, A. Klein-Szanto, R. Amaravadi, N. Avadhani, A. Rustgi, H. Nakagawa, “Autophagy Supports Generation of Cells with High CD44 Expression via Modulation of Oxidative Stress and Parkin-Mediated Mitochondrial Clearance,” Oncogene 2017, 36, 4843-4858.

123. T. Gade, E. Tucker, M. Nakazawa, S. Hunt. W. Wong, B. Krock, C. Weber, G. Madolski, J. Winkler, R. Amaravadi, M. Simon, “Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma,” Radiology 2017, 283, 702-710.

122. L. DeVorkin, M. Hattersley, P. Kim, J. Ries, J. Lum, J. Spowart, M. Anglesio, D. Huntsman, S. Levi, J. Winkler, R. Amaravadi, A. Tinker, “Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma,” Molecular Cancer Research 2017, 15, 250-258.

121. M. Grasso, M. Estrada, C. Ventocilla, M. Samanta, J. Maksimoska, J. Villaneuva, J. Winkler, R. Marmorstein, “Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF/V600E Conformation,” ACS Chemical Biology 2016, 11, 2876-2888.

120. J. Chatwichien, S. Basu, A., Budina-Kolomets, M. Murphy and J. Winkler, “PUMA-Dependent Apoptosis in NSCLC Cancer Cells by a Dimeric β-Carboline, Bioorg. Med. Chem. Lett. 2016, 26, 4884-4887.

119. C. Natale, E. Duperret, J. Zhang, R. Sadeghi, D. Ankit, K. O’Brien, R. Cookson, J. Winkler, T. Ridky “Sex Steroids Regulate Skin Pigmentation Through Nonclassical Membrane-Bound Receptors,” eLife, 2016, 5, e15164. PMID: 27115344.

118. I. Vasilevskaya, M. Selvakumaran, L. Hierro, S. Goldstein, J. Winkler. P. O’Dwyer, “Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA Damaging Agents, “ Clin. Cancer Res. 2015, 21, 4143-4152.

117. Y. Nishimura, N. McLaughlin, J. Pan, S. Goldstein, S. Hafenstein, H. Shimizu, J. Winkler, J. Bergelson, “The Suramin Derivative NF449 Interacts with the 5-Fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 andHeparan Sulfate,” PLOS Pathogens 2015, 11 (10), 1-19.

116. J. Chatwichien, S. Basu, M. Murphy, M. Hamann, J. Winkler, “Design, Synthesis and Biological Evaluation of -Carboline Dimers Based on the Structure of Neokauluamine,” “Tet. Lett. 2015, 56, 3515-3517.

115. V. Hubbard-Lucey, Y. Shono, K. Maurer, M. West, N. Singer, C. Ziegler, C. Lezcano, A. Motta, K. Schmid, S. Levi, G. Murphy, C. Liu, J. Winkler, R. Amaravadi, G. Rogler, A. Dickinson, E. Holler, M. van den Brink, K. Cadwell, “Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells,” Immunity, 2014, 4, 579-591.

114. X. Ma, S. Piao, S. Dey, Q. Mcafee, G. arakousis, J. Villaneuva, L. Hart, S. Levi, J. Hu, G. Zhang, R. Lazova, V. Klump, J. Pawalek, X. Xu, W. Xu, L. Schuchter, M. Davies, M. Herlyn, J. Winkler, C. Koumenis, R. Amaravadi, “ Targeting ER Stress-Induced Autophagy Overcomes BRAF Inhibitor Resistance in Melanoma,” J. Clin. Invest. 2014, 124, 1406-1417.

113. R. Amaravadi, J. Winkler, “Lys05: A New Lysosomal Autophagy Inhibitor,” Autophagy 2012, 8, 1383-1384.

112. M. Chen, A. Adeniji, B. Twenter, J. Winkler, D. Christianson, T. Penning, “Crystal Structures of AKR1C3 Containing an N-(Aryl)amino-benzoate Inhibitor and a Bifunctional AKR1C3 Inhibitor and Androgen Receptor Antagonist. Therapeutic Leads for Castrate Resistant Prostate Cancer,” Bioorg. Med. Chem. Lett. 2012, 22, 3492-3497.

111. J. Qin, P. Xie, C. Ventochilla, G. Zhou, A. Vultur, Q. Chen, Q. Liu, M. Herlyn, J. Winkler, R. Marmorstein, “Identification of a Novel Family of BRAF(V600E) Inhibitors, J. Med. Chem. 2012, 55, 5220-5230.

110. Q. McAfee, Z. Zhang, A. Samanta, S. Levi, X. Ma, S. Piao, J. Lynch, T. Uehara, A. Sepulveda, L. Davis, J. Winkler, R. Amaravadi, “A Novel Autophagy Inhibitor with Single Agent Antitumor Activity Reproduces the Phenotype of a Genetic Autophagy Deficiency,” Proc. Natl. Acad. Sci. 2012, 109, 8253-8258.

109. A. Adeniji, B. Twenter, M. Byrns, U. Jin, M. Chen, J. Winkler, T. Penning, “Development of Potent and Selective Inhibitors of Aldo-Keto Reductase 1C3 (type 5 17-hydroxysteroid dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure Activity Relationships,” J. Med. Chem. 2012, 55, 2311-2323

108. J. Winkler, B. Twenter, T. Gendrineau, “Synthesis of Substituted Phenazines via Palladium-Catalyzed Aryl Ligation,” Heterocycles, 2012, 84, 1345-1353 (invited contribution in honor of Professor Albert Padwa).

107. J. Winkler, A. Isaacs, C. Xiang, V. Baubet, N. Dahmane, “Design, Synthesis and Biological Evaluation of Estrone-Derived Hedgehog Signaling Inhibitors,” Tetrahedron 2011, 67, 10261-10266 (invited contribution in honor of Professor Gilbert Stork).

106. A. Isaacs, C. Xiang, V. Baubet, N. Dahmane, J. Winkler, “Studies Directed toward the Eludication of the Pharmacophore of Steroid-Based Hedgehog Signaling Inhibitors,” Org. Lett 2011, 13, 5140-5143.

105. Z. Zhang, V. Baubet, C. Ventocilla, C. Xiang, N. Dahmane, J. Winkler, “Stereoselective Synthesis of F-Ring Saturated Estrone-Derived Inhibitors of Hedgehog Signaling Based on Cyclopamine,” Org. Lett 2011, 13, 4786-4789.

104. A. Adeniji, B. Twenter, M. Byrns, Y. Jin, J. Winkler, T. Penning, “Discovery of Substituted 3-(Phenylamino)benzoic acids as Potent and Selective Inhibitors of Type 5 17β-Hydroxysteroid Dehydrogenase (AKR1C3),” Bioorg. Med. Chem. Lett, 2011, 21, 1464-1468.

103. T. Haimowitz, M. Fitzgerald, J. Winkler, “Studies Directed Toward the Synthesis of Nakadomarin A,” Tetrahedron Lett. 2011, 52, 2162-2164 (invited contribution in honor of Professor Harry Wasserman).

102. T. Yano, S. Kassovska-Bratinova, J. Teh, J. Winkler, K. Sullivan, A. Isaacs, N. Schechter, H. Rubin, “Reduction of Clofazimine by Mycobaterial Type 2 NADH:Quinone Oxidoreductase: A Pathway for the Generation of Bactericidal Levels of Reactive Oxygen Species,” J. Biol. Chem. 2011, 286, 10276-10287 (doi: 10.1074/ jbc.M110. 200501).

101. J. Winkler, A. Isaacs, L. Holderbaum. V. Tatard, N. Dahmane, “Design and Synthesis of Inhibitors of Hedgehog Signaling Based on the Alkaloid Cyclopamine Org. Lett 2009, 11, 2824-2827.

100. H. Jo, M. Fitzgerald, J. Winkler, “An Unusual Pathway to Cyclobutane Formation via Desulfurative Intramolecular Photocycloaddition to an Enone Benzothiazoline Pair,” Org. Lett 2009, 11, 1685-1687.

99. S. Choi, A. Isaacs, D. Clements, D. Liu, H. Kim. R. Scott, J. Winkler, W. Degrado, “De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers,” Proc. Natl. Acad. Sci, 2009, 106, 6968-6973.

98. J. Winkler, M. Fitzgerald, “Stereoselective Synthesis of 8-Substituted 6-Azabicyclo[3.2.1]-octan-3-ones,” Synlett 2009, 562-564.

97. S. Choi, G. Vilaire, C. Marcinkiewicz, J. Winkler, J. Bennett, W. Degrado, “Small Molecule Inhibitors of Integrin a2b1,” J. Med. Chem. 2007, 50, 5457-5462.

96. J. Winkler, A. Londregan, M. Hamann, “Synthetic Modification of Manzmaine A via Grubbs Metathesis. Novel Structures with Enhanced Antibacterial and Antiprotozoal Properties,” Org. Lett. 2007, 9, 4467-4469.

95. W. Jiang, P. Mikochik, J. Ra, H. Lei, K. Flaherty, J. Winkler, F. Spitz, “HIV Protease Inhibitor Nelfinavir Inhibits Growth of Human Melanoma Cells by Induction of Cell Cycle Arrest,” Cancer Research 2007, 67, 1221-1227.

94. J. Ragains, J. Winkler, “Pseudosymmetry in azabicyclo[2.1.1.]hexanes. A Stereoselective Construction of the Bicyclic Core of the Ring System of Peduncularine,” Org. Lett., 2006, 8, 4437-4440.

93. J. Winkler, S. Asselin, “Synthesis of Novel Heterocyclic Structures via Reaction of Isocyanides with S-trans-Enones,” Org. Lett., 2006, 8, 3975-77.

92. J. Winkler, J. Ragains, “Intramolecular Photocycloaddition of Vinylogous Amides with Allenes: A Novel Approach to the Synthesis of Pyrroles,” Org. Lett., 2006, 8, 4031-33.

91. J. Winkler, A. Londregan, J. Ragains, M. Hamann, “Synthesis and Biological Evaluation of Manzamine Analogues,” Org. Lett., 2006, 8, 3407-3409.

90. J. Winkler, A. Londregan, M. Hamann, “Antimalarial Activity of a New Family of Analogs of Manzamine A,” Org. Lett., 2006, 8, 2591-2594.

89. J. Winkler, E. Lee, “Photochemical Route to the Synthesis of Thiolane 1-Oxides,” J. Am. Chem. Soc. 2006, 128, 9040-9041.

88. W. Wang, W. Ho, D. Dicker, C. MacKinnon, J. Winkler, R. Marmorstein, W. El-Deiry, “Acridine Derivatives Activate p53 and Induce Tumor Cell Death Through Bax,” Cancer Biology and Therapy 2005, i, 893-898.

87. S. Choi, D. Clements, V. Pophristic, I. Ivanov, S. Vemparala, J. Bennett, M. Klein, J. Winkler, W. DeGrado, “The Design and Evaluation of Heparin-Binding Foldamers,” Angew. Chem. Int. Ed. 2005, 44, 6685-6689.

86. J. Winkler, K. Oh, “A One-Step Synthesis of 2,3-Dihydro-4H-pyran-4-ones from 3-Ethoxy , -Unsaturated Lactones,” Org. Lett. 2005, 7, 2421-2423.

85. J. Winkler, E. Lee, L. Nevels, “A Pauson-Khand Approach to the Synthesis of Ingenol,” Org. Lett., 2005, 7, 1489-1491.

84. J. Winkler, K. Oh, S. Asselin, “Synthesis of Highly Functionalized Furanones via Aldol Reaction of 3-Silyloxyfurans,” Org. Lett, 2005, 7, 387-389.

83. J. Winkler, E. McLaughlin, “Intramolecular Photocycloaddition of Dioxenones with Alkynes: Formation of Secondary Photoproducts from Cyclobutene Photoadducts,” Org. Lett, 2005, 7, 227-229.

82. H. Kung, S. Newman, S. Choi, S. Oya, C. Hou, Z. Zhuang, P. Acton, K. Ploessl, J. Winkler, M. Kung, “2-(2-(Dimethylaminomethyl)phenoxy)-5-iodophenylamine: An Improved Serotonin Transporter Imaging Agent,” J. Med. Chem. 2004, 47, 5258-5264.

81. J. Winkler, S. Asselin, S. Shepard, J. Yuan, “Metathesis Approach to the Synthesis of Polyheterocyclic Structures from Oxanorbornenes,” Org. Lett, 2004, 6, 3821-3824.

80. J. Winkler, P. Mikochik, “Synthesis of Cyclic Hemiketals and Spiroketals from Dioxanorbornanes,” Org. Lett, 2004, 6, 3735-3737.

79. D. Liu; S. Choi; B. Chen; R.J. Doerksen; D.J. Clements; J.D. Winkler; M.L. Klein; W.F. DeGrado. “Nontoxic Membrane-Active Antimicrobial Arylamide Oligomers,” Angew. Chem. Int. Ed. 2004, 43, 1158-1162.

78. R. Doerksen, B. Chen, J. Yuan, J. Winkler, M. Klein, “Novel Conformationally-Constrained -Peptides Characterized by 1H NMR Chemical Shifts,,” Chem. Commun., 2003, 2534-2535.

77. J. Winkler, K. Quinn, C. MacKinnon, S. Hiscock, E. McLaughlin, “Tandem Diels-Alder Approach to the Synthesis of Eleutherobin,” Org. Lett. 2003, 5, 1805.

76. J. Winkler, S. Harrison, M. Greaney, M. Rouse, “Mechanistic Observations on the Unusual Reactivity of Dioxenone Photosubstrates in the Synthesis of Ingenol,” Synthesis (Special Issue Dedicated to Professor Dieter Seebach) 2002, 2150.

75. J. Winkler, M. Rouse, M. Greaney, S. Harrison, Y. Jeon, “The First Total Synthesis of Ingenol, J. Am. Chem. Soc. 2002, 124, 9726-9728.

74. G. Collins, R. Morris, J. Wei, M. Smith, M. Hammond, V. Michelet, J. Winkler, “Spectrophotometric Detection of Trace Copper Levels in Jet Fuel,” Energy & Fuels 2002, in press.

73. F. Ichinose, J. Erana-Garcia, J. Hromi, Y. Raveh, R. Jones, L. Krim, M. Clark, J. Winkler, K. Bloch, W. Zapol, “Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension,” Critical Care Medicine 2001, 29, 1000-1005.

72. Y. Kwak, J. Winkler, “Synthesis of 6-Aza-Bicyclo[3.2.1]Octan-3-Ones via Vinylogous Imide Photochemistry: An Approach to the Synthesis of the Hetisine Alkaloids,” J. Am. Chem. Soc. 2001, 123, 7429-7430.

71. J. Winkler, E. Piatnitski, J. Mehlmann, J. Kasparec, P. Axelsen, “Design and Synthesis of Novel Foldamers Based on an Anthracene Diels-Alder Adduct,” Angew. Chem. Int. Ed. Engl. 2001, 40, 743-745.

70. L. Evans, G. Collins, R. Shaffer, V. Michelet, J. Winkler, :Selective Metals Determination with a Photoreversible Spirobenzopyran,” Anal. Chem. 1999, 71, 5322. 5327.

69. J. Winkler, E. Doherty, “ The First Total Synthesis of (+)-Saudin,” J. Am. Chem. Soc. 1999, 121, 7425-7426.

68. J. Axten, R. Ivy, L. Krim, J. Winkler, “An Enantioselective Synthesis of d-threo-Methylphenidate,” J. Am. Chem. Soc. 1999, 121, 6511-6512.

67. J. Winkler, J. Holland, J. Kasparec, and P. Axelsen, “Synthesis and Biological Evaluation of Constrained Epothilone Analogs: The Efficient Synthesis of Eleven-Membered Rings by Olefin Metathesis,” Tetrahedron (invited contribution to Symposium-in-Print on Olefin Metathesis in Synthesis) 1999, 55, 8199-8214.

66. G. Collins, L. Choi, K. Ewing, V. Michelet, C. Bowen, and J. Winkler, “Photoinduced Switching of Metal Complexation by Quinolinospiropyranindolines in Polar Solvents,” J. Chem. Soc., Chem. Commun. 1999, 321-322.

65. J. Winkler, S. Kim, S. Harrison, N. Lewin, P. Blumberg, “Synthesis and Biological Evaluation of Highly Functionalized Analogs of Ingenol: The Importance of Hydrophobic Effects on Binding to Protein Kinase C,” J. Am. Chem. Soc., 1999, 121, 296-300.

64. J. Axten, L. Krim, H. Kung, J. Winkler, “An Improved Synthesis of dl-threo-Methylphenidate. Preparation and Biological Evaluation of Novel Analogs,” J. Org. Chem 1998, 63, 9628-9629.

63. J. Winkler, Y. Kwak, “An Approach to Controlled Oligomerization via Iterative Diels-Alder Cycloadditions on Solid Supports,” J. Org. Chem. 1998, 63, 8634-8635.

62. J. Winkler, J. Axten, “The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D,” J. Am. Chem. Soc. 1998, 120, 6425-6426.

61. J. Winkler, W. McCoull, “Diels-Alder Reaction on Solid Supports Using Polymer-Bound Oxazolidinones,” Tetrahedron Lett. 1998, 4935-4936.

60. J. Winkler, J. Axten, H. Hammach, Y. Kwak, M. Lucero, K. Houk, “Stereoselective Synthesis of the Tetracyclic Core of the Manzamine Alkaloids via the Vinylogous Amide Photocycloaddition Cascade: A Remarkable Effect of Azocine Unsaturation on the Stereochemical Outcome of the Photocycloaddition Reaction,” Tetrahedron 1998, 54, 7045-7056.

59. S. Narasimhulu, L. Havran, P. Axelsen, J. Winkler, “Interactions of Substrate and Product with Cytochrome P450,” Arch. Biochem. Biophys. 1998, 353, 228-238.

58. J. Winkler, C. Bowen, V. Michelet, “Photodynamic Fluorescent Metal Ion Sensors with ppb Sensitivity,” J. Am. Chem. Soc. 1998, 120, 3237-3242.

57. J. Winkler, E. Doherty, “Control of Relative Stereochemistry of Quaternary Carbon Centers via the Intramolecular Dioxenone Photocycloaddition: An Approach to the Synthesis of Saudin,” Tetrahedron Lett. 1998, 2253-2256.

56. S. Kim, J. Winkler, “Approaches to the Synthesis of Ingenol,” Chem. Soc. Rev. 1997, 26, 387-400.

55. J. Winkler, J. Stelmach, M. Siegel, N. Haddad, J. Axten, W. Dailey, “An Approach to the Synthesis of the Manzamine Alkaloids via the Vinylogous Amide Photocycloaddition-retro-Mannich Fragmentation-Mannich Closure Cascade,” Isr. J. Chem. 1997, 37, 47-67.

54. J. Winkler, H. Kim, S. Kim. K. Ando, K. Houk, “Stereoselective Synthesis of the Taxane Ring System via the Tandem Diels-Alder Cycloaddition,” J. Org. Chem. 1997, 62, 2957-2962.

53. J. Winkler and P. Axelsen, “A Model for the Taxol/Epothilone Pharmacophore,” Bioorg. Med. Chem. Lett. 1996, 6, 2963-2966.

52. J. Winkler, J. Holland, D. Peters, “Synthesis of Cyclopropyl Taxane Analogs via Sequential Diels-Alder Reactions,” J. Org. Chem. 1996, 61, 9074-9075.

51. J. Winkler, S. Bhattacharya, R. Batey, “Synthesis of a Taxinine Congener via the Intramolecular Diels-Alder Cycloaddition,” Tetrahedron Lett. 1996, 8069-8072.

50. J. Winkler, J. Stelmach, J. Axten, “Two Highly Efficient Syntheses of Scalemic Azocines,” Tetrahedron Lett. 1996, 4317-4320.

49. J. Winkler, “The Tandem Diels-Alder Reaction,” Chem. Rev. 1996, 96, 167-176.

48. J. Winkler, C. Mazur, and F. Liotta, “[2+2]Photocycloaddition-Fragmentation Strategies for the Synthesis of Natural and Unnatural Products,” Chem. Rev. 1995, 95, 2003-2020.

47. H. Li, S. Narasimhulu, L. Havran, J. Winkler, T. Poulos, “Crystal Structure of Cytochrome P-450 Complexed with Its Catalytic Product, 5-Exo-Hydroxycamphor,” J. Am. Chem. Soc. 1995, 117, 6297-6299.

46. J. Winkler, B. Hong, S. Kim, N. Lewin, P. Blumberg, “On the Protein Kinase C Pharmacophore: Synthesis and Biological Activity of 4-Hydroxylated Analogs of Ingenol,” Synlett 1995, 533-535.

45. J. Winkler, S. Bhattacharya, F. Liotta, R. Batey, G. Heffernan, D. Cladingboel, R. Kelly, “Stereoselective Synthesis of A Synthon for the A-Ring of Taxol from R-(+)-Verbenone,” Tetrahedron Lett. 1995, 2211-2215.

44. J. Winkler, B. Hong, A. Bahador, M. Kazanietz, P. Blumberg, “Methodology for the Synthesis of 3-Oxygenated Ingenanes–The First Ingenol Analogs with High Affinity for Protein Kinase C,” J. Org. Chem. 1995, 60, 1381-1390.

43. J. Winkler, H. Kim, S. Kim, “A Highly Efficient Synthesis of Taxanes via the Tandem Diels-Alder Reaction,” Tetrahedron Lett. 1995, 687-691.

42. J. Winkler, B. Hong, “Transannular Radical Reactions in Bicycloalkanes with ‘Inside-Outside’ Stereochemistry. An Unusual Bridgehead Hydroxylation,” Tetrahedron Lett. 1995, 683-686.

41. J. Winkler, S. Kim, K. Condroski, A. Asensio, K. N. Houk, “Stereoselective Synthesis of Polycyclic Ring Systems via the Tandem Diels-Alder Reaction,” J. Org. Chem. 1994, 59, 6879-6881.

40. K. Davis, T. Berrodin, T., J. Stelmach, J. Winkler, M. Lazar, “Endogenous RXRs can function as hormone receptors in pituitary cells,” Molecular and Cell Biology 1994, 14, 7105-7110.

39. J. Winkler, B. Hong, “Trans-Bicyclo-[5.3.1]undecan-11-one,” in Photochemical Key Steps in Organic Synthesis 1994, J. Mattay and A. Griesbeck, Eds., VCH, Weinheim, 109-111.

38. J. Winkler, K. Henegar, B. Hong and P. Williard, “Inside-Outside Stereoisomerism. 6. Synthesis of trans-Bicyclo[4.4.1]Undecan-11-one and the First Stereoselective Construction of the Ingenane Nucleus,” J. Am. Chem. Soc. 1994, 116, 4183-4188.

37. M. Siegel and J. Winkler, “Photochemistry of Enamines and Enaminones” In The Chemistry of Enamines, 1994, S. Patai and Z. Rappaport, Eds., Wiley, New York, 637-679.

36. J. Winkler, M. Siegel, “A Novel Photochemical Synthesis of Pyrroles from -Ketoviny-logous Amides,” Tetrahedron Lett. 1993, 7697-7700.

35. J. Winkler, K. Deshayes and Bin Shao, “Photochemical Binding, Release and Transport of Metal Ions.” In Bioorganic Photochemistry, 1993, Volume II, H. Morrison, Ed., Wiley, New York, Chapter 3, pp. 169-196.

34. J. Winkler, M. Siegel, and J. Stelmach, “A Highly Stereoselective Approach to the Synthesis of the Manzamine Alkaloids via the Intramolecular Vinylogous Amide Photocycloaddition,” Tetrahedron Lett. 1993, 6509-6512.

33. J. Winkler, B. Shao, “On the Stereoselectivity of the Intramolecular Dioxenone Photocycloaddition Reaction,” Tetrahedron Lett. 1993, 3355-3358.

32. J. Winkler, B. Hong, A. Bahador, M. Kazanietz, P. Blumberg, “Synthesis of Ingenol Analogs with Affinity for Protein Kinase C,” Bioorg. Med. Chem. Lett. 1993, 3, 577-580.

31. J. Winkler, E. Gretler, P. Williard,”Studies Directed Towards the Synthesis of the Ingenane Diterpenes. An Unexpected Synthesis of trans-Bicyclo[5.3.0]Decanes,” J. Org. Chem. 1993, 58, 1973-1975.

30. J. Winkler and D. Subrahmanyam, “Studies Directed Towards the Synthesis of Taxol: Preparation of C-13 Oxygenated Taxane Congeners,” Tetrahedron 1992, 48, 7049-7056.

29. J. Winkler, E. Gretler, “Stereoselective Cyclopropanation of Homoallylic Alcohols. Formal Attachment of a Cyclopropane to a Preexisting Ring,” Tetrahedron Lett. 1991, 5733-36.

28. J. Winkler, B. Hong, “Inside-Outside Stereoisomerism V. Synthesis and Reactivity of Bicyclo[n.3.1]alkanones with trans Intrabridgehead Stereochemistry,” J. Am. Chem. Soc. 1991, 113, 8839-8846.

27. J. Winkler, R. Scott, P. Williard, “Asymmetric Induction in the Vinylogous Amide Photocycloaddition. A Formal Synthesis of Vindorosine,” J. Am. Chem. Soc. 1990, 112, 8971-8975.

26. J. Winkler, M. Finck-Estes, “Carbon-Carbon Bond Formation Under Aqueous Reaction Conditions Using Sulfonium and Selenonium Salt Electrophiles,” Tetrahedron Lett. 1989, 7293-7296.

25. J. Winkler, N. Haddad, R. Ogilvie, “Intramolecular Photocycloaddition and Retro-Mannich Fragmentation of Tertiary Vinylogous Amides,” Tetrahedron Lett. 1989, 5703-5704.

24. J. Winkler, C. Muller, J. Hey, R. Ogilvie, N. Haddad, P. Squattrito, P. Williard, “The Effect of Chromophore Transposition on the Stereochemical Outcome of the Intramolecular Dioxenone Photocycloaddition Reaction,” Tetrahedron Lett. 1989, 5211-5214.

23. J. Winkler, V. Sridar, M. Siegel, “Ten-Membered Ring Templates for Stereoselective Radical Cyclizations,” Tetrahedron Lett. 1989, 4943-4946.

22. J. Winkler, C. Lee, L. Rubo, C. Muller, P. J. Squattrito, “Stereoselective Synthesis of the Tricyclic Skeleton of the Taxane Diterpenes. The First C-Silylation of a Ketone Enolate,” J. Org. Chem. 1989, 54, 4491-4493.

21. J. Winkler, V. Sridar, L. Rubo, J. Hey, N. Haddad, “Inside-Outside Stereoisomerism IV. An Unusual Rearrangement of the trans-Bicyclo[5.3.1]Undecan-11-yl Radical,” J. Org. Chem. 1989, 54, 3004-3006.

20. J. Winkler, P. Hershberger, “A Stereoselective Synthesis of (-)-Perhydrohistrionicotoxin,” J. Am. Chem. Soc. 1989, 111, 4852-4856.

19. J. Winkler, K. Deshayes, B. Shao, “Photodynamic Systems for Metal Ion Transport,” J. Am. Chem. Soc. 1989, 111, 769-770.

18. J. Winkler, V. Sridar, “Eight-Membered Ring Templates for Stereoselective Radical Cyclizations,” Tetrahedron Lett. 1988, 6219-6222.

17. J. Winkler, J. Hey, P. Williard, “Inside-Outside Stereoisomerism III. The Synthesis of trans-Bicyclo[4.3.1]Decan-10-one,” Tetrahedron Lett. 1988, 4691-4694.

16. J. Winkler, C. Muller, R. Scott, “A New Method for the Formation of Nitrogen-Containing Ring Systems via the Intramolecular Photocycloaddition of Vinylogous Amides. A Synthesis of Mesembrine,” J. Am. Chem. Soc. 1988, 110, 4831-4832.

15. K. Henegar, J. Winkler, “A New Method for the Synthesis of Dioxolenones via the Carboxylation of Ketone Enolates with Anisyl Cyanoformate,” Tetrahedron Lett. 1987, 1051-1054.

14. J. Winkler, K. Henegar, P. Williard, “Inside-Outside Stereoisomerism II. Synthesis of the Carbocyclic Ring System of the Ingenane Diterpenes via the Intramolecular Dioxolenone Photocycloaddition,” J. Am. Chem. Soc. 1987, 109, 2850-2851.

13. J. Winkler, K. Deshayes, “Photodynamic Macrocycles,” J. Am. Chem. Soc. 1987, 109, 2190-2191.

12. J. Winkler, J. Hey, F. Hannon, P. Williard, “Intramolecular Photoaddition of Dioxolenones. An Efficient Method for the Synthesis of Medium-Sized Rings,” Heterocycles 1987, 25, 55-60.

11. J. Winkler, J. Hey, S. Darling, “Studies Directed Towards the Synthesis of the Taxane Diterpenes: A Remarkable Rearrangement,” Tetrahedron Lett. 1986, 5959-5962.

10. J. Winkler, P. Hershberger, J. Springer, “A Stereoselective Synthesis of the Azaspiroundecane Ring System of (-)-Histrionicotoxin from (+)-Glutamic Acid,” Tetrahedron Lett. 1986, 5177-5180.

9. J. Winkler, J. Hey, P. Williard, “Inside-Outside Stereoisomerism: A Synthesis of trans-Bicyclo[5.3.1]undecan-11-one,” J. Am. Chem. Soc. 1986, 108, 6425-6427.

8. J. Winkler, V. Sridar, “Stereochemical Control of Transannular Radical Cyclizations. A New Approach to the Synthesis of Linearly Fused Cyclopentanoids,” J. Am. Chem. Soc. 1986, 108, 1708-1709.

7. R. Breslow, A. W. Czarnik, M. Lauer, H. Leppkes, J. Winkler, S. Zimmerman, “Mimics of Transaminase Enzymes,” J. Am. Chem. Soc. 1986, 108, 1969-1979.

6. W. Weiner, J. Winkler, S. Zimmerman, R. Breslow, “Mimics of Tryptophan Synthetase and of Biochemical Dehydroalanine Formation,” J. Am. Chem. Soc. 1985, 107, 4093-4094.

5. J. Winkler, E.Coutouli-Argyropoulou, R. Leppkes, R. Breslow, “An Artificial Transaminase Carrying A Synthetic Macrocyclic Binding Group,” J. Am. Chem. Soc. 1983, 105, 7198-7199.

4. G. Stork, J. Winkler, N. Saccomano, “Stereochemical Control in the Construction of Vicinally Substituted Cyclopentanes and Cyclohexanes. Intramolecular Conjugate Addition of -Ketoester Anions,” Tetrahedron Lett. 1983, 465-468.

3. G. Stork, J. Winkler, C. Shiner, “Stereochemical Control of Intramolecular Conjugate Addition. A Short, Highly Stereoselective Synthesis of Adrenosterone,” J. Am. Chem. Soc. 1982, 104, 3767-3768.

2. G. Stork, C. Shiner, J. Winkler, “Stereochemical Control of the Internal Michael Reaction. A New Construction of trans-Hydrindane Systems,” J. Am. Chem. Soc. 1982, 104, 310-312.

1. L. Blaszczak, J. Winkler, S. O’Kuhn, “A New Synthesis of Olefins from Ketones via Coupling of Lithium Dialkylcuprates with Enol Phosphate Diesters,” Tetrahedron Lett. 1976, 4405-4408.