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Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

  • October 2021 – Chris Brue joined the lab as a post-doc; he comes from the Meade lab at Northwestern University. Welcome Chris!
  • October 2021 – Buyan left for her post-doc in the Rapoport lab at Harvard- good luck and we will miss you!
  • September 2021 – Chemistry graduate student, Bethann Flint, joins us for a rotation.
  • September 2021 – Fulbright Scholar Nuno Bernardes arrived in lab. He will be studying the role of cellular glycans in cancer using FCS.
  • July 2021 – Buyan successfully defended her thesis. Congratulations, Dr. Pan!
  • July 2021 – Chemistry graduate student, Emily Brackhan, officially joined the lab.
  • July 2021 – Liz became co-director of the Vagelos Molecular Life Sciences Program.
  • June 2021 – We welcomed undergraduate Amy Wu to the lab to work on neurexin/alpha-synuclein interactions.
  • June 2021 – Buyan was selected to give a talk in the “Molecular Basis of
    Proteinopathies” seminar series. Congratulations, Buyan!
  • May 2021 – Yifan graduated from Haverford. Way to go Yifan! He will be spending the next year doing research in the lab of Fei Chen at the Broad Institute.
  • May 2021 – Karen’s paper with the Sachs lab at University of Minnesota
    was accepted by npj Parkinson’s Disease.
  • May 2021 – Jenny was reappointed to the CBI training grant –
    congratulations Jenny!
  • April 2021 – Chemistry graduate student Emily Brackhahn joined us for a
    rotation.
  • April 2021 – Liz gave a talk in the “Experimental and Computational
    Approaches in Unraveling Mechanisms of Amyloid Formation” session at the
    ACS Meeting. Buyan gave a talk in the Organic Division.
  • April 2021 – Buyan’s paper on phosphorylated alpha-synuclein appeared in
    ChemBioChem – yay Buyan!

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