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Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

  • July 2020 – Liz has been promoted to Full Professor! Her promotion has been formally approved by the University. Congratulations, Liz!
  • June 2020 – We welcome BMB first year student Emily Pillet for a rotation.
  • June 2020 – We are beginning to emerge from the shutdown and found that
    all our lasers are still working!
  • June 2020 – Isabel presented a poster at the virtual EMBL Symposia
    ‘Microtubules: From Atoms to Complex Systems’
  • June 2020 – Haverford undergraduate Yifan Zhang joined the lab (remotely!).
  • June 2020 – Congratulations to Jenny for earning a spot on the Chemical
    Biology Training Grant!
  • May 2020 – Jenny passed her candidacy exam – way to go, Jenny!
  • March 2020 – We welcomed postdoc Nima Naseri from Manu Sharma’s lab at
    Weill Cornell to the group! (Then the lab shut-down, but we don’t blame
    Nima)
  • March 2020 – Buyan’s paper appeared in ACS Chemical Biology – yay, Buyan!
  • Feburary 2020 – Kristen successfully defended her PhD thesis (only a
    week before her wedding!) – congratulations, Dr. McKibben!

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