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Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

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Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

  • June 2020 – We are beginning to emerge from the shutdown and found that
    all our lasers are still working!
  • June 2020 – Isabel presented a poster at the virtual EMBL Symposia
    ‘Microtubules: From Atoms to Complex Systems’
  • June 2020 – Haverford undergraduate Yifan Zhang joined the lab (remotely!).
  • June 2020 – Congratulations to Jenny for earning a spot on the Chemical
    Biology Training Grant!
  • May 2020 – Jenny passed her candidacy exam – way to go, Jenny!
  • March 2020 – We welcomed postdoc Nima Naseri from Manu Sharma’s lab at
    Weill Cornell to the group! (Then the lab shut-down, but we don’t blame
    Nima)
  • March 2020 – Buyan’s paper appeared in ACS Chemical Biology – yay, Buyan!
  • Feburary 2020 – Kristen successfully defended her PhD thesis (only a
    week before her wedding!) – congratulations, Dr. McKibben!
  • January 2020 – Liz gave at talk at the GRC on “Protein Folding Dynamics”
    in Galveston – don’t mess with Texas!
  • January 2020 – BMB graduate student Roseanne Davila-Rivera joined us for
    research rotation – welcome Roseanne!
  • January 2020 – Undergraduate Will Shafer joined the lab – welcome Will!
  • December 2019 – Congratulations to lab alum, Joyce, and current lab members Kristen and Jenny on their paper accepted at Structure.
  • November 2019 – Congratulations to Kristen on her paper on tau’s proline rich region and N-terminal domain accepted at Journal of Biological Chemistry!
  • October 2019 – We welcome Chemistry graduate student Karthik Narayan
    for a research rotation.
  • September 2019 – We say goodbye to postdoc Jonathan – good luck in North Carolina!
  • August 2019 – Sanju’s paper on tau aggregation by polyphosphate with the Jakob lab came out in Biophysical Journal.
  • July 2019 – Jenny Ramirez joins the lab as a joint student with the Petersson lab. Welcome, Jenny!
  • July 2019 – Buyan’s collaborative paper on the structure and mechanism of NatA/Naa50 with the Marmorstein lab came out in Structure.
  • June 2019 – Liz gave talks at the GRC on Proteins and the FASEB meeting on Protein Aggregation.
  • June 2019 – Buyan presented a poster at the American Peptide Society meeting and won a Peptide Science Poster Award. Read her feature on the APS website: »
  • May 2019 – Congratulations to Melissa for her paper on alpha-synuclein and N-linked glycans being accepted at PLoS Biology!
  • May 2019 – Liz gave a keynote address at the Chesapeake Bay Single Molecule Meeting at the Janelia Research Campus.
  • May 2019 – We say good-bye to Adriana. We are delighted she will be returning to UPenn as a PhD student this summer!
  • May 2019 – Buyan presented a poster at the NYAS Chemical Biology Meeting and won a poster prize. Congratulations, Buyan!
  • May 2019 – Congratulations to Isabel on passing her candidacy exam!

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