Home

Welcome to the Rhoades lab!

We are interested in understanding the underlying principals that govern the functions of intrinsically disordered proteins and why these proteins are so frequently associated with disease.  To do this, we use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions.

This slideshow requires JavaScript.

 

Currently, the proteins of interest to our group include tau, α-synuclein, islet amyloid polypeptide, and troponin.

Single molecule fluorescence – applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) – is an elegant and powerful approach to studying biological molecules and processes.

Lab News

    • June 2021 – Buyan was selected to give a talk in the “Molecular Basis of
      Proteinopathies” seminar series. Congratulations, Buyan!
    • May 2021 – Yifan graduated from Haverford. Way to go Yifan! He will be spending the next year doing research in the lab of Fei Chen at the Broad Institute.
    • May 2021 – Karen’s paper with the Sachs lab at University of Minnesota
      was accepted by npj Parkinson’s Disease.
    • May 2021 – Jenny was reappointed to the CBI training grant –
      congratulations Jenny!
    • April 2021 – Chemistry graduate student Emily Brackhahn joined us for a
      rotation.
    • April 2021 – Liz gave a talk in the “Experimental and Computational
      Approaches in Unraveling Mechanisms of Amyloid Formation” session at the
      ACS Meeting. Buyan gave a talk in the Organic Division.
    • April 2021 – Buyan’s paper on phosphorylated alpha-synuclein appeared in
      ChemBioChem – yay Buyan!
    • February 2021 – Buyan presented a poster at the Biophysical Society Virtual Annual Meeting.
    • January 2021 – Liz gave a talk in the “Molecular Basis of
      Proteinopathies” seminar series.
    • January 2021 – We welcome BMB graduate student Christina Hurley for a
      virtual research rotation.
    • December 2020 – Buyan’s paper on glutamate arginylation of
      alpha-synuclein was published in JACS.
    • December 2020 – Melissa left us to start her Group Leader position at
      the Max Delbruck Institute of Molecular Medicine. Good luck, Melissa and
      we’ll miss you!

    See more…