HTE Center

In 2009, the University of Pennsylvania, via a $1 million GOALI grant from the NSF, developed a center for microscale High Throughput Experimentation (HTE), using state-of-the-art facilities to develop novel methods and solve difficult transformations in a rapid, efficient, and cost effective manner. In fact, screening many different conditions can be a long and problematic process when dealing with expensive or delicate starting materials.

We are proposing here to utilize our ten years of experience in microscale High Throughput Experimentation, allowing for general reactions to be run at 1/10th normal scale. The development of sealable 24 or 96 well reactor blocks allows screening to a variety of different reactions under conditions your chemistry demands. Cutting edge catalysts and an extensive compound collection make for rapid screen preparation.

With LCMS, GCMS and SFC analytics, the best reaction conditions can be determined quickly. From conception to state-of-the-art reactions conditions, the High Throughput Experimentation center can accommodate your needs.

“High Throughput Experimentation for reaction optimization has transformed the way we do science in my group. It allows us to tackle extremely challenging and important problems, with the surety of sampling the broadest range of reaction space in the shortest time possible.”

Prof. Gary A. Molander, Hirschmann-Makineni Professor of Chemistry, University of Pennsylvania

The Screening Center of the University of Pennsylvania is a facility accessible to academia as well as industry. For more information, please email us at or

To read more about the efficiency of the High Throughput Experimentation facility, please visit the “Publications” section.