Wie, J., Liu, L., Song, H., Tropea, T.F., Yang, L., Wang, H., Liang, Y., Cang, C., Aranda, K., Lohmann, J., Yang, J., Lu, B., Chen-Plotkin, A.S. , Luk, K.C.. and Ren, D. (2021) A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology. Nature 591: 431-437 (link)

Cang, C., Lu, B. and Ren, D. (2020) Epilepsy-associated Mutations in the Calcium-sensing Receptor Disrupt the Regulation of NALCN Sodium-leak Channel by Extracellular Calcium in Neurons. BioRxiv (link).

Wie, J., Bharthur, A., Wolfgang, M., Narayanan, V., Ramsey, K., C4RCD Research Group, Aranda, K., Zhang, Q., Zhou, Y. and Ren, D. (2020) Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Nature Commun. 2020 Jul 3;11(1):3351. (link).

Freeman, S.A., Uderhardt, S., Saric, A., Collins, R.F., Buckley, C.M., Mylvaganam, S., Boroumand, P., Plumb, J., German, R.N., Ren, D. and Grinstein, S. (2019) Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science 367:301-305. doi: 10.1126/science.aaw9544. Epub 2019 Dec 5.  (link)

Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH. (2018) ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation. Science Signaling 2018 Dec 18;11(561). pii: eaat0358. doi: 10.1126/scisignal.aat0358. (link)

Ford, N.C., Ren, D. and Baccei, M.L. (2018) NALCN channels enhance the intrinsic excitability of spinal projection neurons. Pain 159: 1719-1730 (link)

Hirschi, L.*, Herzik, M.A.*, Wie, J., Suo, Y., Borschel, W.F., Ren, D., Lander, G.C. & Lee, S.-Y. (2017) Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature 550:411-414 (link)

Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C (2017) Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes. Nature Protocols 12: 1639-1658 (link)

Lee, C., Guo, J., Zeng, W., Ki, S., She, J., Cang, C., Ren, D. and Jiang, Y. (2017) The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547:472-475 (link)

Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D and Zoghbi HY (2017) Respiratory network stability and modulatory response to substance P require Nalcn. Neuron 94:294-303 (link)

Guo, J., Zeng, W., Chen, Q. Lee, C., Chen, L. Yang, Y., Cang, C., Ren, D. and Jiang, Y. (2016) Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana. Nature 531:196-201 (link)

Stray-Pedersen, A., Jan-Maarten Cobben, Trine E. Prescott, T.E, Lee, S., Cang, C., Aranda, K., Ahmed, S., Alders, M., Gerstner, T., Aslaksen, K., Tétreault, M., Qin, W., Hartley, T., Jhangiani, S.N., Muzny, D.M., Maja Tarailo-Graovac, Clara DM van Karnebeek, Care4Rare Canada Consortium, Baylor Hopkins Center for Mendelian Genomics, Lupski, J.R., Ren, D.* and Yoon, G.* (2016) Biallelic mutations in UNC80 cause persistent hypotonia, encephalopathy, growth retardation, and severe intellectual disability. Am J Hum Genet 98:202-9 (link)

Cang, C., Aranda, K., Seo, Y.-J., Gasnier, B. and Ren, D. (2015) TMEM175 is an organelle K+ channel regulating lysosomal function. Cell 162: 1101-1112 (link)

Flourakis, M., Kula-Eversole, E., Hutchison, A.L., Han, T.H, Aranda, K., Moose, D.L., White, K.P., Dinner, A.R., Lear, B.C., Ren, D., Diekman, C.D., Raman, I.M., and Allada, R. (2015) A Conserved bicycle model for circadian clock control of membrane excitability. Cell 162: 836-848 (link)

Xu, H. and Ren, D. (2015) Lysosomal Physiology. Annu. Rev. Physiol. 77:57-80 (link)

Cang, C., Bekele, B. and Ren, D. (2014) The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nature Chem. Biol. 10: 463-469 (link)

Cang, C., Aranda, K. and Ren, D. (2014) A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability. Nature Commun. 5: 5015, DOI: 10.1038/ncomms6015 (link)

Cang, C.*, Zhou, Y.*, Navarro, B., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. and Ren, D. (2013) mTOR Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channels to Adapt to Metabolic State. Cell 152: 778-790 (link)

Wang, X., Zhang, X., Dong, X.-P., Samie, M., Li, X., Cheng, X., Goschka, A., Shen, D., Zhou, Y., Harlow, J., Zhu, M.-X., Clapham, D.E., Ren, D., and Xu, H. (2012) TPC proteins are phosphoinositide-activated sodium-selective ion channels in endosomes and lysosomes. Cell 151:372-383 (link)

Ren, D. (2011) Sodium leak channels in neuronal excitability and rhythmic behaviors. Neuron 72: 899-911 (link)

Lishko, P., Kirichok, Y., Ren, D., Navarro, B., Chung, J.-J., and Clapham, D.E. (2011) The control of male fertility by spermatozoan ion channels. Annu. Rev. Physiol. 74: 453-475 (link)

Ren D. (2010) Sperm and the proton channel. N Engl J Med 362: 1934-5 (link)

Lu, B., Zhang, Q., Wang, H., Wang, Y., Nakayama, M. and Ren, D. (2010) Extracellular Calcium Controls Background Current and Neuronal Excitability via an UNC79-UNC80-NALCN Cation Channel Complex. Neuron 68:488-499 (link)

Ren, D. and Xia, J. (2010) Calcium signaling through CatSper channels in mammalian fertilization. Physiology 25: 165-75 (link)

Wang, H. and Ren, D. (2009) UNC80 functions as a scaffold for Src kinases in NALCN channel function. Channels 3: 161-163 (link)

Lu, B.*, Su, Y.*, Das, S., Wang, H., Wang, Y., Liu, J. and Ren, D. (2009) Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature 457:741-744 (link)

Xia, J. and Ren, D. (2009) Egg coat proteins activate Ca2+ entry into mouse sperm via CatSper channels. Biol. Reprod. 80:1092-1098 (link)

Wang, H., Liu, J., Cho, K-H. and Ren, D. (2009) A novel, single transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol. Reprod. 81: 539-544 (link)

Xia, J. and Ren, D. (2009) CATSPER channels contribute the BSA-induced Ca2+ influx during sperm capacitation. Reprod. Biol. Endocrinol. 7:119 (link)

Xia, J., Reigada, D., Mitchell, C.H. and Ren, D. (2007) CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Biol. Reprod. 77: 551-559 (link)

Liu, J., Xia, J., Cho, K-H., Clapham, D.E. and Ren, D. (2007) CatSperβ, a novel transmembrane protein in the CatSper channel complex. J. Biol. Chem. 282: 18945-18952. (link)

Lu, B., Su, Y., Das, S., Xia, J., Liu, J. and Ren, D. (2007) The neuronal NALCN channel contributes resting sodium permeability and is required for normal respiratory rhythm. Cell 129: 371-378. (link)

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