drosophilaOur research launches from the fly Drosophila as a model for human neurodegenerative disease. We are focused on genes involved in ALS/FTD, like TDP-43 and on risk factors like traumatic brain injury and aging. Our research defines the fascinating molecular mechanisms by which human disease genes cause toxic effects, how the neurons become dysfunctional, how they degenerate, and of course ways to interfere with these processes to provide the framework for molecular understanding and therapeutic insight.