drosophilaOur research is focused on using the fly Drosophila to study human neurodegenerative disease. We are focused on one of the polyglutamine diseases called Spinocerebellar ataxia type 3, on Spinocerebellar ataxia type 2 and on genes involved in ALS/FTD, like TDP-43. Our research is directed toward defining the molecular mechanisms by which the disease genes cause toxicity, how the neurons become dysfunctional, how they degenerate, ways to interfere with these processes to provide the foundation for therapeutic insight, as well as risk factors such as ageing.