A paper in Proceedings of the National Academy of Sciences of the United States of America entitled “Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers” was published recently by our group and highlighted by E. K. Brockmeier “A new tool for cell biologists” in Penn Today. This work is a collaboration between Penn, Temple University, the Max Planck Institute, the Leibniz Institute for Interactive Materials, RWTH Aachen University, and Freie Universität Berlin, This story demonstrated how our research on synthetic vesicles coated with oligomannose can do for coronavirus.
A paper in Proceedings of the National Academy of Sciences of the United States of America was published recently by the Percec group and highlighted by E. K. Brockmeier “Cells use sugars to communicate at the molecular level” in Penn Today.
The paper reports by using atomic force microscopy images that were fast fourier-transformed, we found that sugars on the surface of synthetic cells organize themselves automatically into thin lamellar layered and hexagonal patterns. The shapes that the sugar molecules form allows the synthetic cells to be recognized by other cells and also enhances their reactivity with proteins.
Professor Virgil Percec Commented on C&EN News on 2019 ACS Award in Polymer Chemistry for Professor Timothy M. Swager, John D. MacArthur Professor of Chemistry, Massachusetts Institute of Technology. Chemical & Engieering News, 2019, 97 (3), 50-51.
“Tim is one of the most creative scientists working in the field of polymer chemistry and is a leader of our field. He is one of the very few members of our community who has taken polymer chemistry from fundamental development to commercial products that impact our daily life and create a safer society.”—Virgil Percec, University of Pennsylvania.
Previous awardees of ACS Award in Polymer Chemistry
A recent paper from the group on the functional pairing between glycoconjugates and galectins has been highlighted in a Commentary in the Proceedings of the National Academy of Sciences (PNAS), written by Kamil Godula of UC San Diego. The original paper, also published in PNAS and led by Qi Xiao, unravels intricate aspects of the mechanism underlying the interactions between the cell glycan and proteins in its environment.
Feature image adapted from Kamil Godula’s Commentary.