A paper in Proceedings of the National Academy of Sciences of the United States of America entitled “Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers” was published recently by our group and highlighted by E. K. Brockmeier “A new tool for cell biologists” in Penn Today. This work is a collaboration between Penn, Temple University, the Max Planck Institute, the Leibniz Institute for Interactive Materials, RWTH Aachen University, and Freie Universität Berlin, This story demonstrated how our research on synthetic vesicles coated with oligomannose can do for coronavirus.
Category: New Publication
New Paper in PNAS Highlighted by Penn Today
A paper in Proceedings of the National Academy of Sciences of the United States of America was published recently by the Percec group and highlighted by E. K. Brockmeier “Cells use sugars to communicate at the molecular level” in Penn Today.
The paper reports by using atomic force microscopy images that were fast fourier-transformed, we found that sugars on the surface of synthetic cells organize themselves automatically into thin lamellar layered and hexagonal patterns. The shapes that the sugar molecules form allows the synthetic cells to be recognized by other cells and also enhances their reactivity with proteins.
Three-step one-pot methodology for functionalization of sterically hindered polyacrylates
A new publication from the group in Polymer Chemistry addresses the functionalization of sterically hindered polyacrylates. Unlike poly(methyl acrylate) (PMA), the chain ends of which can be reacted quantitatively after polymerization, the chain ends of poly(butyl acrylate) (PBA) show lower reactivity due to steric encumbrance. In this work, a three step methodology involving biphasic SET-LRP, chain extension with methyl acrylate and heterogeneous esterification provides a route to acrylate-functionalized PBA. This approach, which can be simplified by applying two or even all three steps in a single pot, may provide a more general route to the funcationalization of sterically hindered polyacrylates.
This work was led in the group by Adrian Moreno with contributions from Tong Liu, as part of a collaboration with the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.
SET-LRP Applied to Hydrophobic Biobased Menthyl Acrylate
Recent collaborative work from the group broadening the scope of SET-LRP has been published in Biomacromolecules. The new paper details the polymerization of menthyl acrylate, a monomer derived from biobased and renewable menthol. This monomer’s hydrophobicity, which might be expected to be problematic for SET-LRP, instead causes the reaction to self-generate a biphasic system, in which SET-LRP proceeds cleanly.
This work was led by the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.
SET-LRP’s High Chain End Functionality Exploited to Create Complex Architecture
Recent work published by the group in Polymer Chemistry utilizes one of the key features of single-electron transfer-living radical polymerization (SET-LRP): the high chain end functionality of the resulting polymers. In this work, led in our group by Adrian Moreno with contributions from Ryan L. Jezorek and Tong Liu, functional end groups of poly(methyl acrylate) (PMA) are exploited for esterification to generate PMA macromonomers and telechelics.
This work was conducted as part of a collaboration with the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.
Latest Paper in PNAS Unravels the Complexity of Lectin-Carbohydrate Interactions
The group has published a new paper in Proceedings of the National Academy of Sciences. The work presents a platform for interrogating the binding interactions between lectins and carbohydrates via agglutination assays. This approach is applied to understand the complex interplay between lectin structure, glycodendrimersome surface charge, glycan density, and cross-linking.
The work was led in our group by Qi Xiao with contributions from Irene Buzzacchera and Samuel E. Sherman, as part of a multidisciplinary collaborative effort with the groups of Hans-Joachim Gabius (Ludwig-Maximilians-University, Munich, Germany), Daniel A. Hammer (Penn), Michael L. Klein (Temple University, Philadelphia) and Martin Möller (RWTH Aachen University, Aachen, Germany).
New Work Uses Cheaper TREN as Ligand for SET-LRP
The group has published a new paper in Polymer Chemistry. The work examines the replacement of Me6-TREN, a common ligand for SET-LRP, by TREN, which is 80 times cheaper. It is shown that high chain end functionality and controlled polymer growth can be achieved in a diverse range of water-organic solvent mixtures, further reducing the cost of SET-LRP for large-scale application.
The work was led in our group by Adrian Moreno and Silvia Grama, as part of a collaboration with the group of Gerard Lligadas at University Rovira i Virgili, Tarragona, Spain.
New Paper in Angewandte Chemie Designated as a Hot Paper
A paper recently published by the group in Angewandte Chemie International Edition has been designated as a Hot Paper. The paper reports the use of glycodendrimersomes as a platform for the interrogation of sugar binding to a variety of natural and engineered human lectins, to examine the impact of spatial factors on aggregation activity. It was discovered that two aspects of lectin functionality respond non-uniformly to structural changes in the lectins.
The work was led in our group by Qi Xiao in collaboration with researchers from Ruprecht-Karls-University Heidelberg (Germany), Ludwig-Maximilians-University Munich (Germany), CSIC Ramiro de Maeztu (Spain), and Temple University (Philadelphia, PA).