A paper recently published by the group in Angewandte Chemie International Edition has been designated as a Hot Paper. The paper reports the use of glycodendrimersomes as a platform for the interrogation of sugar binding to a variety of natural and engineered human lectins, to examine the impact of spatial factors on aggregation activity. It was discovered that two aspects of lectin functionality respond non-uniformly to structural changes in the lectins.

The work was led in our group by Qi Xiao in collaboration with researchers from Ruprecht-Karls-University Heidelberg (Germany), Ludwig-Maximilians-University Munich (Germany), CSIC Ramiro de Maeztu (Spain), and Temple University (Philadelphia, PA).